Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.

http://www.wikidata.org/entity/Q36534389

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Nutrition and the risk of Alzheimer's disease Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's Disease Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice Dementia, Preclinical Studies in Neurodegeneration and its Potential for Translational Medicine in South America Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease.Effects of diet on brain plasticity in animal and human studies: mind the gap.Evaluation of plant phenolic metabolites as a source of Alzheimer's drug leads.A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications.Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment.Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease.Recommendations for Development of New Standardized Forms of Cocoa Breeds and Cocoa Extract Processing for the Prevention of Alzheimer's Disease: Role of Cocoa in Promotion of Cognitive Resilience and Healthy Brain Aging.Recommendations for Development of Botanical Polyphenols as "Natural Drugs" for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment.Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.Inhibition of microglial activation by elderberry extracts and its phenolic components.Bioavailability of Plant-Derived Antioxidants Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction.Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose.Pharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS.Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression.Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction.Dietary factors affecting polyphenol bioavailability.Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update.Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability.A comprehensive database and analysis framework to incorporate multiscale data types and enable integrated analysis of bioactive polyphenols.Recent Findings in Alzheimer Disease and Nutrition Focusing on Epigenetics.Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action.Role of dietary phenols in mitigating microglia-mediated neuroinflammation.Polyphenols journey through blood-brain barrier towards neuronal protection.The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans.Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria.Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study.Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice.Glucuronidated Flavonoids in Neurological Protection: Structural Analysis and Approaches for Chemical and Biological Synthesis.Diabetes and Alzheimer's Disease: Can Tea Phytochemicals Play a Role in Prevention?Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat.Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model.

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P2860

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.

http://www.wikidata.org/entity/Q36534389

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Identification of brain-target ...... ntion for Alzheimer's disease.

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Bing Gong

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Bruce Cooper

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Elsa M Janle

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Giulio Maria Pasinetti

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James E Simon

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Jessica Lobo

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Jun Wang

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Qing Li Wu

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Stephen T Talcott

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Susan S Percival

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P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

A synaptic model of memory: long-term potentiation in the hippocampus

Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

Polyphenols: food sources and bioavailability

Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration.

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice

Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin.

Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS.

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769-781

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10.1096/FJ.12-212118

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Mario G Ferruzzi

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232700359

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23097297

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Alzheimer's disease

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