Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
about
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signalingRac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion featuresGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersThe constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens.A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling.Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.Ca²⁺ and calpain control membrane expansion during the rapid cell spreading of neutrophils.The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.Germinal center B cells recognize antigen through a specialized immune synapse architecture.One-way membrane trafficking of SOS in receptor-triggered Ras activation.B cell activation triggered by the formation of the small receptor cluster: a computational study.HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memoryPathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.It's all about change: the antigen-driven initiation of B-cell receptor signalingEncoding immunological memory in the initiation of B-cell receptor signalingThe membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.How B cells capture, process and present antigens: a crucial role for cell polarity.Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.BANK1 and BLK act through phospholipase C gamma 2 in B-cell signalingDynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity.N-wasp is essential for the negative regulation of B cell receptor signaling.Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cellsThe β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearanceNovel Pathways Revealed in Bursa of Fabricius Transcriptome in Response to Extraintestinal Pathogenic Escherichia coli (ExPEC) Infection.PI3Ks in lymphocyte signaling and developmentActin reorganization is required for the formation of polarized B cell receptor signalosomes in response to both soluble and membrane-associated antigens.The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold.A conformation-induced oligomerization model for B cell receptor microclustering and signalingThe tipping points in the initiation of B cell signalling: how small changes make big differences.Strategies to circumvent humoral immunity to adeno-associated viral vectors.CD23 can negatively regulate B-cell receptor signaling.Rho family GTPases and their regulators in lymphocytes.Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells
P2860
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P2860
Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@ast
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@en
type
label
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@ast
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@en
prefLabel
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@ast
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@en
P2093
P2860
P356
P1476
Phospholipase C-gamma2 and Vav ...... onse to membrane-bound antigen
@en
P2093
Bebhinn Treanor
David Depoil
Facundo D Batista
Masaki Hikida
Naomi E Harwood
Tomohiro Kurosaki
P2860
P304
P356
10.1084/JEM.20072619
P407
P577
2008-03-24T00:00:00Z