Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression.
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Involvement of heparanase in atherosclerosis and other vessel wall pathologiesMicroglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory ResponseModification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice.Versatile role of heparanase in inflammationReducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.Involvement of Heparanase in Empyema: Implication for Novel Therapeutic ApproachesTLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion.Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer ActivityToll-like Receptors in the Vascular System: Sensing the Dangers Within.Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathwayHeparanase is required for activation and function of macrophages.Heparanase interacts with resistin and augments its activity.Loss of syndecan-1 induces a pro-inflammatory phenotype in endothelial cells with a dysregulated response to atheroprotective flow.Heparanase in inflammation and inflammation-associated cancer.Oxidation and modification of extracellular matrix and its role in disease.Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesisInvolvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target.Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis.Heparanase: From basic research to therapeutic applications in cancer and inflammation.Heparanase and macrophage interplay in the onset of liver fibrosis.Heparanase Inhibition Reduces Glucose Levels, Blood Pressure, and Oxidative Stress in Apolipoprotein E Knockout Mice.The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.Heparan Sulfate Proteoglycans as Relays of Neuroinflammation.DPP-4 inhibitors repress NLRP3 inflammasome and interleukin-1beta via GLP-1 receptor in macrophages through protein kinase C pathway.Serum heparanase concentration and heparanase activity in patients with retinal vein occlusion.Algal Polysaccharides as Therapeutic Agents for Atherosclerosis
P2860
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P2860
Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Macrophage activation by hepar ...... iates with plaque progression.
@ast
Macrophage activation by hepar ...... iates with plaque progression.
@en
type
label
Macrophage activation by hepar ...... iates with plaque progression.
@ast
Macrophage activation by hepar ...... iates with plaque progression.
@en
prefLabel
Macrophage activation by hepar ...... iates with plaque progression.
@ast
Macrophage activation by hepar ...... iates with plaque progression.
@en
P2093
P2860
P1476
Macrophage activation by hepar ...... iates with plaque progression.
@en
P2093
Amnon Eitan
Amnon Golan
Anat Sebbag
Doron Aronson
Edmond Sabo
Elena Axelman
Gabriel Nussbaum
Gil Arvatz
Haim Hammerman
Israel Vlodavsky
P2860
P304
P356
10.1161/ATVBAHA.112.254961
P407
P577
2012-11-15T00:00:00Z