Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation
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Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activityHeparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VIIExtracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning.Involvement of heparanase in atherosclerosis and other vessel wall pathologiesHeparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycansPG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma modelMelanoma Brain Metastasis: Mechanisms, Models, and MedicineInsights into the key roles of proteoglycans in breast cancer biology and translational medicineNewly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinasesMechanisms of heparanase inhibitors in cancer therapy.An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation.Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationA low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx.Expression of heparanase in soft tissue sarcomas of adults.A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.Versatile role of heparanase in inflammationLRP-1 Pathway Targeted Inhibition of Vascular Abnormalities in the Retina of Diabetic Mice.Heparanase cooperates with Ras to drive breast and skin tumorigenesisTumorigenic and adhesive properties of heparanase.Heparanase enhances myeloma progression via CXCL10 downregulation.Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression.Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.Prognostic value of heparanase expression and cellular localization in oral cancer.Heparanase and coagulation-new insights.PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical modelsMammalian heparanase: what is the message?Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activitySST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotypeHeparanase activates the syndecan-syntenin-ALIX exosome pathway.PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samplesPost-transcriptional regulation of heparanase gene expression by a 3' AU-rich elementHeparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survivalThe role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesisHigh glucose-induced intestinal epithelial barrier damage is aggravated by syndecan-1 destruction and heparanase overexpression.Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significances
P2860
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P2860
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Heparanase induces vascular en ...... tion levels and Src activation
@ast
Heparanase induces vascular en ...... tion levels and Src activation
@en
Heparanase induces vascular en ...... tion levels and Src activation
@en-gb
Heparanase induces vascular en ...... tion levels and Src activation
@nl
type
label
Heparanase induces vascular en ...... tion levels and Src activation
@ast
Heparanase induces vascular en ...... tion levels and Src activation
@en
Heparanase induces vascular en ...... tion levels and Src activation
@en-gb
Heparanase induces vascular en ...... tion levels and Src activation
@nl
prefLabel
Heparanase induces vascular en ...... tion levels and Src activation
@ast
Heparanase induces vascular en ...... tion levels and Src activation
@en
Heparanase induces vascular en ...... tion levels and Src activation
@en-gb
Heparanase induces vascular en ...... tion levels and Src activation
@nl
P2093
P50
P921
P3181
P1433
P1476
Heparanase induces vascular en ...... tion levels and Src activation
@en
P2093
Anna Zetser
Evgeny Edovitsky
Yulia Bashenko
P304
P3181
P356
10.1158/0008-5472.CAN-05-1811
P407
P577
2006-02-01T00:00:00Z