Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase
about
Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocyclineMinocycline inhibits peritoneal macrophages but activates alveolar macrophages in acute pancreatitis.PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell functionPARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.ApoE deficiency promotes colon inflammation and enhances inflammatory potential oxidized-LDL and TNF-α in colon epithelial cells.Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma.DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency.A pilot, open-label, 8-week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression.Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice.
P2860
Q27342233-9B867062-9CA2-41E1-A86D-9F34E0F3EE55Q35839574-1A5316BF-DD37-4FF9-9276-066570175F00Q35848889-D85DE8AF-29E8-4D18-894A-71BA0660B286Q36184688-C5920BBB-97BF-4656-99F8-366328E15B33Q37315219-3274593F-DB62-4991-8D3C-D9E7FE38C8AAQ38954348-F9D6F7D6-F914-4F54-B00A-DFED1787ADDCQ40232460-1654F792-CE80-44DA-9118-0DA547DF5B8DQ41484629-F5FD08DC-9015-4746-A40B-BEB2D3B1BCBEQ43142166-0FE6B45E-434C-4996-951E-A0DEFD9AF232Q47861374-15044EE5-7E6A-41A7-9737-BB8FC65A7B59Q48361783-4E1545FF-33CF-44AE-9A58-60F156F01FE3
P2860
Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@ast
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@en
type
label
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@ast
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@en
prefLabel
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@ast
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@en
P2093
P2860
P356
P1476
Minocycline blocks asthma-asso ...... on poly(ADP-ribose) polymerase
@en
P2093
A Hamid Boulares
Abdelmetalab F Tarhuni
Amarjit S Naura
Andrew D Catling
Augusto C Ochoa
Bashir M Rezk
Hogyoung Kim
Kusma Pyakurel
Mohammad Q Abughazleh
P2860
P304
P356
10.1074/JBC.M112.419580
P407
P577
2012-11-26T00:00:00Z