Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

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PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells.

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Q37680199-E970D4A0-1B18-47F7-85E6-C2E944271225 Q48111623-484FD660-F501-4CA8-B49D-379CB5AD0C13

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Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Small molecule inhibition of t ...... ic taxane resistance in cancer

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Donald Harvey

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Fadlo R Khuri

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Ge Li

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Johann C Brandes

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Paula M Vertino

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Seth A Brodie

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P2860

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity

Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer

Chfr is required for tumor suppression and Aurora A regulation

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

TiGER: a database for tissue-specific gene expression and regulation

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30773-30786

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scholarly article

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10.18632/ONCOTARGET.5040

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English

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2015-09-01T00:00:00Z

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281686529

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26356822

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4741567

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Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

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P2860

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932