Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
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Apolipoprotein O is mitochondrial and promotes lipotoxicity in heartMitochondria in the diabetic heartThe mitochondria in diabetic heart failure: from pathogenesis to therapeutic promiseMitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomesFunctional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heartRedox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular diseaseMitochondrial dysfunction in diabetic cardiomyopathyMonoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart SurgeryInsulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) miceIncreased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria.Diastolic dysfunction in diabetes and the metabolic syndrome: promising potential for diagnosis and prognosisDiabetic cardiomyopathy, causes and effects.Cardiac remodeling in obesity.Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunctionImpaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic heartsMitochondrial adaptations to physiological vs. pathological cardiac hypertrophy.PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.Cardiomyocyte triglyceride accumulation and reduced ventricular function in mice with obesity reflect increased long chain Fatty Acid uptake and de novo Fatty Acid synthesis.Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heartFatty heart, cardiac damage, and inflammation.Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistanceEffect of limb demand ischemia on autophagy and morphology in mice.Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse HeartThe PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium.Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study.Nonischemic heart failure in diabetes mellitus.Predictors and prevention of diabetic cardiomyopathy.Adaptation and maladaptation of the heart in obesity.Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.Diabetic cardiomyopathy: Pathophysiology, diagnostic evaluation and management.Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization.The diabetic cardiomyopathy.
P2860
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P2860
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
@ast
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
@en
type
label
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
@ast
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
@en
prefLabel
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
@ast
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
@en
P2860
P1433
P1476
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes
@en
P2093
Sihem Boudina
P2860
P304
P356
10.1152/PHYSIOL.00008.2006
P50
P577
2006-08-01T00:00:00Z