Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein
about
Severe anaemia is not associated with HIV-1 env gene characteristics in Malawian childrenAccess of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptorsAcute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoyThe human immunodeficiency virus type 1 gp120 V2 domain mediates gp41-independent intersubunit contacts.Cellular immune selection with hepatitis C virus persistence in humansHigh-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infectionStructure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Molecular architecture of native HIV-1 gp120 trimersUnliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loopsBioinformatic analysis of HIV-1 entry and pathogenesis.V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodiesAutologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeysHIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine developmentComparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines.Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1).HIV-1 envelope subregion length variation during disease progressionVisualization of retroviral envelope spikes in complex with the V3 loop antibody 447-52D on intact viruses by cryo-electron tomography.Autoantibodies induced by chimeric cytokine-HIV envelope glycoprotein immunogens.Comparative immunogenicity of subtype a Human Immunodeficiency Virus type 1 envelope exhibiting differential exposure of conserved neutralization epitopesRole of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophagesDonor and recipient envs from heterosexual human immunodeficiency virus subtype C transmission pairs require high receptor levels for entryBiologic and genetic characterization of a panel of 60 human immunodeficiency virus type 1 isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccines.An envelope modification that renders a primary, neutralization-resistant clade B human immunodeficiency virus type 1 isolate highly susceptible to neutralization by sera from other clades.Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeysThe C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates.Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains.Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domainsAssociation of structural changes in the V2 and V3 loops of the gp120 envelope glycoprotein with acquisition of neutralization resistance in a simian-human immunodeficiency virus passaged in vivo.Cross-subtype neutralizing antibodies induced in baboons by a subtype E gp120 immunogen based on an R5 primary human immunodeficiency virus type 1 envelope.Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variantsDifferential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein.The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner.Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120.Broader HIV-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the EIAV attenuated vaccine.Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution.Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection.
P2860
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P2860
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Replication and neutralization ...... he gp120 envelope glycoprotein
@ast
Replication and neutralization ...... he gp120 envelope glycoprotein
@en
type
label
Replication and neutralization ...... he gp120 envelope glycoprotein
@ast
Replication and neutralization ...... he gp120 envelope glycoprotein
@en
prefLabel
Replication and neutralization ...... he gp120 envelope glycoprotein
@ast
Replication and neutralization ...... he gp120 envelope glycoprotein
@en
P2093
P2860
P1433
P1476
Replication and neutralization ...... he gp120 envelope glycoprotein
@en
P2093
E Desjardin
J Robinson
J Sodroski
N Sullivan
P2860
P304
P407
P577
1997-12-01T00:00:00Z