Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases.
about
Alcohol, insulin resistance and the liver-brain axisOverexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liverInsulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signalingAlcohol-induced disruption of endocrine signalingImmunological approach to hepatocellular carcinoma.Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells.Insulin receptor substrates (IRSs) and breast tumorigenesis.Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma.Activation of signal transduction pathways during hepatic oncogenesisHeparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma.Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only.Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cellsExpression and function of the insulin receptor substrate proteins in cancerA carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype.Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling.Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules.The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC.Combination of cetuximab and rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma.TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of Kym-1 rhabdomyosarcoma cells.Insulin resistance and hepatocarcinogenesis.Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts.Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines.A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.Matrix-independent activation of phosphatidylinositol 3-kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros-transformed chicken embryo fibroblasts.Regulation of adipogenesis by a transcriptional repressor that modulates MAPK activation.Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells.Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth.Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation.Synergistic premalignant effects of chronic ethanol exposure and insulin receptor substrate-1 overexpression in liver.The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus.
P2860
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P2860
Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Overexpression of human insuli ...... gen-activated protein kinases.
@ast
Overexpression of human insuli ...... gen-activated protein kinases.
@en
type
label
Overexpression of human insuli ...... gen-activated protein kinases.
@ast
Overexpression of human insuli ...... gen-activated protein kinases.
@en
prefLabel
Overexpression of human insuli ...... gen-activated protein kinases.
@ast
Overexpression of human insuli ...... gen-activated protein kinases.
@en
P2093
P2860
P356
P1476
Overexpression of human insuli ...... gen-activated protein kinases.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.3.943
P407
P577
1996-03-01T00:00:00Z