The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.
about
TEL is a sequence-specific transcriptional repressorTel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion proteinThe human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cellsThe MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion proteinA domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactionsThe inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressorMolecular mechanisms of ETS transcription factor-mediated tumorigenesisPolymerization of the SAM domain of TEL in leukemogenesis and transcriptional repressionA mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemiaAML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoterAML1 interconnected pathways of leukemogenesisThe RUNX genes: gain or loss of function in cancerYolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TELThe leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repressionIdentification of the regions involved in DNA binding by the mouse PEBP2alpha protein.Runx1/AML1 in normal and abnormal hematopoiesis.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.A new gene selection procedure based on the covariance distance.Nuclear structure/gene expression interrelationships.Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.Childhood B-acute lymphoblastic leukemia: a genetic update.Cytogenetics and molecular genetics of childhood leukemia.Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association.Regulation of Ets function by protein - protein interactions.Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.Molecular biology of leukemia.Differential display as an approach to study differentiation and differentiation therapy in AML.Proteins of the ETS family with transcriptional repressor activity.Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element.Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genesRunx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressorRole of AML1/Runx1 in the pathogenesis of hematological malignancies.
P2860
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P2860
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The t(12;21) translocation con ...... a repressor of transcription.
@ast
The t(12;21) translocation con ...... a repressor of transcription.
@en
type
label
The t(12;21) translocation con ...... a repressor of transcription.
@ast
The t(12;21) translocation con ...... a repressor of transcription.
@en
prefLabel
The t(12;21) translocation con ...... a repressor of transcription.
@ast
The t(12;21) translocation con ...... a repressor of transcription.
@en
P2093
P2860
P356
P1476
The t(12;21) translocation con ...... a repressor of transcription.
@en
P2093
D G Gilliland
G Grosveld
J R Downing
M F Roussell
S Shurtleff
S W Hiebert
P2860
P304
P356
10.1128/MCB.16.4.1349
P407
P577
1996-04-01T00:00:00Z