about
Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI InhibitorsSmall-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1αOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesDesigning focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methodsUpdates on drug-target network; facilitating polypharmacology and data integration by growth of DrugBank database.SAR by oxime-containing peptide libraries: application to Tsg101 ligand optimization.Discovery of small peptide antagonists of PED/PEA15-D4α interaction from simplified combinatorial libraries.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and interventionDesign and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.Structure-based design of small-molecule protein-protein interaction modulators: the story so far.Resolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90Medicinal chemistry for 2020State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Ligand discovery and virtual screening using the program LIDAEUS.Inhibition of protein-protein interaction of HER2-EGFR and HER2-HER3 by a rationally designed peptidomimetic.Targeting synuclein-gamma to counteract drug resistance in cancer.Protein-protein interactions as targets for small-molecule therapeutics in cancer.Template-constrained macrocyclic peptides prepared from native, unprotected precursorsKnitting and untying the protein network: modulation of protein ensembles as a therapeutic strategy.A strategy based on protein-protein interface motifs may help in identifying drug off-targets.Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3.Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction.Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction.Conformationally constrained peptides from CD2 to modulate protein-protein interactions between CD2 and CD58.Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin LigasesChiral Sulfoxide-Induced Single Turn Peptide α-Helicity.Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)-H activation.Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface.Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology.Discovery of new druggable sites in the anti-cholesterol target HMG-CoA reductase by computational alanine scanning mutagenesis.Computer aided design of FtsZ targeting oligopeptidesUncovering new disease indications for G-protein coupled receptors and their endogenous ligands
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Drugs targeting protein-protein interactions.
@ast
Drugs targeting protein-protein interactions.
@en
type
label
Drugs targeting protein-protein interactions.
@ast
Drugs targeting protein-protein interactions.
@en
prefLabel
Drugs targeting protein-protein interactions.
@ast
Drugs targeting protein-protein interactions.
@en
P2860
P356
P1433
P1476
Drugs targeting protein-protein interactions.
@en
P2093
Patrick Chène
P2860
P304
P356
10.1002/CMDC.200600004
P577
2006-04-01T00:00:00Z