Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
about
Cloning and characterization of a family of proteins associated with MplMpl traffics to the cell surface through conventional and unconventional routesDissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domainThrombopoietin signal transduction requires functional JAK2, not TYK2Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitorsErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationA senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferationThrombopoietin.Molecular control of megakaryopoiesis and thrombopoiesis.(R)evolutionary considerations in hematopoietic development.Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell lineThrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathwaysStructural and functional hot spots in cytokine receptors.Autocrine role of angiopoietins during megakaryocytic differentiationPermissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiationActivation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors.Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway.Cytokine receptors and hematopoietic differentiation.Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.Design of conditionally active STATs: insights into STAT activation and gene regulatory function.Orientation-specific signalling by thrombopoietin receptor dimers.Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation.Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation.Megakaryocytic Maturation is Regulated by Maintaining a Balance Against Cytokine Induced-cell Proliferation: Steel Factor Retards Thrombopoietin-induced Megakaryocytic Differentiation While Synergistically Stimulating Mitogenesis; Hematopoiesis.Selective modification of eukaryotic initiation factor 4F (eIF4F) at the onset of cell differentiation: recruitment of eIF4GII and long-lasting phosphorylation of eIF4E.Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e.A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl.Thrombopoietin stimulates proliferation and megakaryocytic differentiation of mouse pro-B cell line BF-TE22Thrombopoietin-induced expression of the glycoprotein IIb gene involves the transcription factor PU.1/Spi-1 in UT7-Mpl cells.Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain.Identification of functional domains of the human thrombopoietin receptor required for growth and differentiation of megakaryocytic cells.The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway.A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts.OTT-MAL is a deregulated activator of serum response factor-dependent gene expression
P2860
Q24292135-0884D86D-9E9A-4AD3-98C5-1AF34E8916BFQ24299221-185A18AB-04AE-4927-9804-AC4F53A9FF1DQ24564909-DF927C68-58BF-4EB5-AE15-976E0586B8DBQ28142867-416D7A13-A0D8-4C4B-9F8A-4C70431C8AD0Q28201470-7CCFEF18-74D0-4EDE-9DFD-A3B33650B34BQ28238908-986509F8-6814-4236-8887-AAC1AAC3093BQ28251507-8F833975-5D2C-4A9D-9E0D-381AD6000C9FQ28475435-8C53792C-5C20-443E-AB93-A487EE36213FQ33330090-B882CD56-D079-47E4-87D0-F6E8C001A59AQ33343081-AF7DB9BB-CA60-458A-936C-D6D0C5F6C5E5Q33661816-DEE49D98-1FD5-46E1-8C2A-296AB580CE91Q33775054-A56A1019-E329-4EC7-8DCC-DADF2895496BQ33967880-5289A957-CB62-4AEC-9F63-8596A100B8E8Q34246732-C31940AD-AA0F-4C7E-85AB-AFC5FDBD8ABFQ34335730-2445EE5B-E74E-439D-9563-46C71738A93DQ34847758-2E0D1FF4-445D-46A3-9D9D-435C65CAE8B0Q34985773-99217A7F-3BB8-4820-A0EE-16AD83F11A82Q35915787-A4440829-8561-4875-93C2-E5FD8962D3E7Q35989404-CEBE229B-0A46-41D7-A9B7-85C89AC0CC30Q36066346-F4C0B377-EB65-4133-BD6F-6948EEC516F5Q36571164-F3F3C576-CD49-4568-A14C-FF778A86D953Q36970182-8F6574C6-F8E0-40A1-A70C-2F18F2D7FD04Q38352135-A4BE3F2E-6BD9-4E93-91B8-363EB4E2D754Q39445261-60D87EE2-A4B8-4C0F-A31E-19B216EE4E30Q39592020-6983764E-B1AA-484B-99CC-ECB070F34765Q40022229-A4B711A2-58BC-4CA1-8981-F85755923E8BQ40729360-BA32E2C2-5C05-4A65-B1C6-FFC87CFF0426Q40735322-D2409025-1C72-4764-94BF-B079AA9F7C21Q40799496-1C7BD721-A021-41DF-A864-372F8A91CB45Q40886501-59879BFF-1B89-40F2-B30D-C2588C334A8CQ40899370-A41954BE-7460-4681-B088-7ED43595D289Q40970057-748860C1-69B0-45F8-8678-5B13789AD798Q41027781-FE985F4D-6780-43E6-9DBC-B2ADF361C3BAQ41047876-41867521-C186-4D0C-B16B-C2332A2FCAE6Q41090064-67B9B2CF-366B-445A-B7B5-00EC2DC50531Q41115157-35F8E2D4-E6C2-4AA5-B05A-15F22A198840Q41120984-4F47D0A7-6034-4B2F-B679-4B0C7457BE47Q41929935-EED469B2-5AAF-4860-A8EB-C157C1B1E91EQ42802190-28872EF9-FA48-48EF-BB7C-02474F05F558Q42809415-995BF10C-33FA-4E68-8450-C6496CBA31AF
P2860
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Functional regions of the mous ...... complemented by erythropoietin
@ast
Functional regions of the mous ...... complemented by erythropoietin
@en
type
label
Functional regions of the mous ...... complemented by erythropoietin
@ast
Functional regions of the mous ...... complemented by erythropoietin
@en
prefLabel
Functional regions of the mous ...... complemented by erythropoietin
@ast
Functional regions of the mous ...... complemented by erythropoietin
@en
P2093
P2860
P356
P1476
Functional regions of the mous ...... complemented by erythropoietin
@en
P2093
Dusanter-Fourt I
Gisselbrecht S
P2860
P304
P356
10.1128/MCB.16.5.2473
P407
P577
1996-05-01T00:00:00Z