Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.
about
Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function propertiesRadicals: Reactive Intermediates with Translational PotentialTotal synthesis of (-)-kopsinine and ent-(+)-kopsinineTotal Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.Total synthesis of kopsinine.Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates.Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Palladium-catalyzed transformations of salvinorin A, a neoclerodane diterpene from Salvia divinorum.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.Natural product analogues: towards a blueprint for analogue-focused synthesis.Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.A Photoredox-Induced Stereoselective Dearomative Radical (4+2)-Cyclization/1,4-Addition Cascade for the Synthesis of Highly Functionalized Hexahydro-1H-carbazoles.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent.
P2860
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P2860
Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Total synthesis and evaluation ...... it ring system: core redesign.
@ast
Total synthesis and evaluation ...... it ring system: core redesign.
@en
type
label
Total synthesis and evaluation ...... it ring system: core redesign.
@ast
Total synthesis and evaluation ...... it ring system: core redesign.
@en
prefLabel
Total synthesis and evaluation ...... it ring system: core redesign.
@ast
Total synthesis and evaluation ...... it ring system: core redesign.
@en
P2093
P2860
P356
P1476
Total synthesis and evaluation ...... it ring system: core redesign.
@en
P2093
Daisuke Kato
Dale L Boger
Katharine K Duncan
Kristin D Schleicher
Yoshikazu Sasaki
P2860
P304
P356
10.1021/JM3014376
P407
P577
2013-01-04T00:00:00Z