Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain
about
Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.Nicastrin guards Alzheimer's gateAlzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratioThe interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.Amyloid precursor protein processing and bioenergetics.An Inducible Reconstitution System for the Real-Time Kinetic Analysis of Protease Activity and Inhibition Inside the Membrane.A Systematic Review and Critical Evaluation of Reported Pathogenic Sequence Variants in Hidradenitis Suppurativa.Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.Enzymatic Assays for Studying Intramembrane Proteolysis.Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approachHigh-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100Probing γ-secretase-substrate interactions at the single amino acid residue level.The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.Allosteric Modulation of Intact γ-Secretase Structural Dynamics.Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases.Involvement of a conserved GFG motif region in substrate binding by RseP, an Escherichia coli S2P protease.Bacillus subtilis Intramembrane Protease RasP Activity in Escherichia coli and In Vitro.Taking a position on intramembrane proteolysis.Efficient production of a mature and functional gamma secretase protease
P2860
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P2860
Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Nicastrin functions to sterica ...... substrate transmembrane domain
@ast
Nicastrin functions to sterica ...... substrate transmembrane domain
@en
type
label
Nicastrin functions to sterica ...... substrate transmembrane domain
@ast
Nicastrin functions to sterica ...... substrate transmembrane domain
@en
prefLabel
Nicastrin functions to sterica ...... substrate transmembrane domain
@ast
Nicastrin functions to sterica ...... substrate transmembrane domain
@en
P2093
P2860
P356
P1476
Nicastrin functions to sterica ...... substrate transmembrane domain
@en
P2093
Daniel R Montagna
David M Bolduc
Dennis J Selkoe
Michael S Wolfe
P2860
P304
P356
10.1073/PNAS.1512952113
P407
P577
2015-12-22T00:00:00Z