Thymocyte development is normal in CTLA-4-deficient mice
about
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor proteinEarly-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.The role of CTLA-4 in the regulation of T cell immune responses.Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.Inhibitors of B7-CD28 costimulation in urologic malignancies.Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses.Immune tolerance induction by integrating innate and adaptive immune regulators.CTLA-4--the costimulatory molecule that doesn't: regulation of T-cell responses by inhibition.Organ-specific autoimmune disease: a deficiency of tolerogenic stimulationSingle dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenanceLack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.Modeling CTLA4-linked autoimmunity with RNA interference in micePinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cellsCytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.The B7/CD28 costimulatory family in autoimmunity.Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking.Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells.Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancerInduction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyGlobal T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunityEnhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic toleranceB7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.Shaping the T-cell repertoire: a matter of life and death.Role of parathymic lymph nodes in metastatic tumor development.Ipilimumab in prostate cancer.Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma.Basics of PD-1 in self-tolerance, infection, and cancer immunity.CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
P2860
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P2860
Thymocyte development is normal in CTLA-4-deficient mice
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Thymocyte development is normal in CTLA-4-deficient mice
@ast
Thymocyte development is normal in CTLA-4-deficient mice
@en
type
label
Thymocyte development is normal in CTLA-4-deficient mice
@ast
Thymocyte development is normal in CTLA-4-deficient mice
@en
prefLabel
Thymocyte development is normal in CTLA-4-deficient mice
@ast
Thymocyte development is normal in CTLA-4-deficient mice
@en
P2093
P2860
P356
P1476
Thymocyte development is normal in CTLA-4-deficient mice
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.17.9296
P407
P577
1997-08-01T00:00:00Z