CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. - Wikidata - awgldk - TriplyDB

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.

http://www.wikidata.org/entity/Q39730366

about

Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs A bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.CD28 and ITK signals regulate autoreactive T cell trafficking.The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplants Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.Foxo transcription factors control regulatory T cell development and function Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.[The role of co-inhibitory signals driven by CTLA-4 in immune system].T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota.Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease Induction of T cell anergy: integration of environmental cues and infectious tolerance.Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.Genetic susceptibility to autoimmune liver disease The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function Peripheral education of the immune system by colonic commensal microbiota.Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes.Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.Increased T regulatory cells lead to development of Th2 immune response in male SJL mice CD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway.Tumor infiltrating regulatory T cells: tractable targets for immunotherapy.Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family Immune checkpoints in central nervous system autoimmunity.Treg and CTLA-4: two intertwining pathways to immune tolerance.Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade.Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.Pharmacological Modulation of Proton Channel Hv1 in Cancer Therapy: Future Perspectives.Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?

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CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.

http://www.wikidata.org/entity/Q39730366

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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name

CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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type

label

CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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Nature Immunology

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CTLA-4 suppresses the pathogen ...... and cell-extrinsic mechanisms.

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Anish Suri

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Hyang Mi Lee

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Katherine M Nutsch

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Kenneth M Murphy

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Masako Kohyama

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Theresa L Murphy

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Wataru Ise

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P2860

NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling

CTLA-4 ligation blocks CD28-dependent T cell activation

Structure of murine CTLA-4 and its role in modulating T cell responsiveness

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Reversal of the TCR stop signal by CTLA-4

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

CTLA-4 control over Foxp3+ regulatory T cell function

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10.1038/NI.1835

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2

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11

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40786331

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1021874855

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20037585

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3235641

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