Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. - Wikidata - awgldk - TriplyDB

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

http://www.wikidata.org/entity/Q36572588

about

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2 Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451 Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance Oncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer Cells G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells Elucidating distinct roles for NF1 in melanomagenesis Negative feedback regulation of the ERK1/2 MAPK pathway Ras-induced cellular events (review)The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions Trihydrophobin 1 is a new negative regulator of A-Raf kinase Raf kinases in cancer-roles and therapeutic opportunities The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling Stimulation of protein kinase C-dependent and -independent signaling pathways by bistratene A in intestinal epithelial cells BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint Functional components of basic fibroblast growth factor signaling that inhibit lung elastin gene expression Suppression of replicative senescence by rapamycin in rodent embryonic cells Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)Extracellular matrix and integrin signalling: the shape of things to come Modulation of mammalian life span by the short isoform of p53.H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair.p21 in cancer: intricate networks and multiple activities ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway.Roles for p21waf1/cip1 and p27kip1 during the adaptation response to massive intestinal resection.

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P2860

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

http://www.wikidata.org/entity/Q36572588

description

1997 nî lūn-bûn

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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1997年论文

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1997年论文

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name

Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

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Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

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type

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Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

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Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

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prefLabel

Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

@ast

Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

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Molecular and Cellular Biology

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Raf-induced proliferation or c ...... th arrest mediated by p21Cip1.

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P2093

Bosch E

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Cherwinski H

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Lees E

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McMahon M

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Parry D

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Woods D

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P2860

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

Mammalian Ras interacts directly with the serine/threonine kinase Raf

WAF1, a potential mediator of p53 tumor suppression

MAP kinase pathways in yeast: for mating and more.

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

Activation of the MAP kinase pathway by the protein kinase raf

P304

5598-5611

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scholarly article

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10.1128/MCB.17.9.5598

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9

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17

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9271435

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P932

232408

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