Cell-based models to study hepatic drug metabolism and enzyme induction in humans. - Wikidata - awgldk - TriplyDB

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

http://www.wikidata.org/entity/Q36572634

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TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms Liver tissue engineering in the evaluation of drug safety.Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes.Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.Organotypic liver culture models: meeting current challenges in toxicity testing.Functional evolution of the pregnane X receptor.Luminogenic cytochrome P450 assays.A tryptophan derivative, ITE, enhances liver cell metabolic functions in vitro.Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.Microfluidic platforms for hepatocyte cell culture: new technologies and applications.Cell patterning for liver tissue engineering via dielectrophoretic mechanisms.Drug metabolism and drug interactions: potential application to antituberculosis drugs.Growth and Development Symposium: Development, characterization, and use of a porcine epiblast-derived liver stem cell line: ARS-PICM-19.Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence.Microstructuring of multiwell plates for three-dimensional cell culture applications by ultrasonic embossing.Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism.Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

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P2860

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

http://www.wikidata.org/entity/Q36572634

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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2005年论文

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2005年论文

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name

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

@ast

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

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type

label

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

@ast

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

@en

prefLabel

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

@ast

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

@en

P1433

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P698

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P356

17425255.1.1.75

P1433

Expert Opinion on Drug Metabolism & Toxicology

P1476

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

@en

P2093

Dirk Roymans

http://www.w3.org/2001/XMLSchema#string

Geert Mannens

http://www.w3.org/2001/XMLSchema#string

Marc Vermeir

http://www.w3.org/2001/XMLSchema#string

Pieter Annaert

http://www.w3.org/2001/XMLSchema#string

Rao N V S Mamidi

http://www.w3.org/2001/XMLSchema#string

Willem Meuldermans

http://www.w3.org/2001/XMLSchema#string

P2860

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

Present and future in vitro approaches for drug metabolism.

Possible applications of conditionally immortalized tissue cell lines with differentiation functions.

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel.

Fetal hepatic drug elimination.

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction.

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.

Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.

P304

75-90

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P31

scholarly article

P356

10.1517/17425255.1.1.75

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P433

1

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P478

1

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P577

2005-06-01T00:00:00Z

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P698

16922654

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