Present and future in vitro approaches for drug metabolism.
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XMetDB: an open access database for xenobiotic metabolismIn vitro metabolic stability of exendin-4: pharmacokinetics and identification of cleavage productsCombining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug DiscoveryOpen Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery DatasetsPrecompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug developmentPrediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes.Can the Internet help to meet the challenges in ADME and e-ADME?Role of traditional Islamic and Arabic plants in cancer therapy.Effect of benzo(a)pyrene exposure on fluoranthene metabolism by mouse adipose tissue microsomes.Identification of In Vitro Metabolites of Amoxicillin in Human Liver Microsomes by LC-ESI/MS.The use of selective adsorbents in capillary electrophoresis-mass spectrometry for analyte preconcentration and microreactions: a powerful three-dimensional tool for multiple chemical and biological applications.Interactions of herbs with cytochrome P450.In vitro metabolism studies of erythraline, the major spiroalkaloid from Erythrina verna.Food-drug interactions via human cytochrome P450 3A (CYP3A).Comparative evaluation of 11 in silico models for the prediction of small molecule mutagenicity: role of steric hindrance and electron-withdrawing groups.Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo.Antidepressant-drug interactions are potentially but rarely clinically significant.Computational prediction of human drug metabolism.Cell-based models to study hepatic drug metabolism and enzyme induction in humans.Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenatesIn vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations.Predictive tools for the evaluation of microbial effects on drugs during gastrointestinal passage.An evaluation of the latest in vitro tools for drug metabolism studies.Antitumor activity of DMAKO-05, a novel shikonin derivative, and its metabolism in rat liver microsome.Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.Enhanced oral bioavailability and anti-tumour effect of paclitaxel by 20(s)-ginsenoside Rg3 in vivo.Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model systemNegligible Pharmacokinetic Interaction of Red Ginseng and Losartan, an Antihypertensive Agent, in Sprague-Dawley Rats.Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices.How is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation?Comparison of Deep Learning With Multiple Machine Learning Methods and Metrics Using Diverse Drug Discovery Data Sets.Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.Negligible pharmacokinetic interaction of red ginseng and antihypertensive agent amlodipine in Sprague-Dawley rats.Reaction temperature alters chorzoxazone metabolism in carp (Cyprinus carpio) hepatic microsomes.
P2860
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P2860
Present and future in vitro approaches for drug metabolism.
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Present and future in vitro approaches for drug metabolism.
@ast
Present and future in vitro approaches for drug metabolism.
@en
type
label
Present and future in vitro approaches for drug metabolism.
@ast
Present and future in vitro approaches for drug metabolism.
@en
prefLabel
Present and future in vitro approaches for drug metabolism.
@ast
Present and future in vitro approaches for drug metabolism.
@en
P2093
P1476
Present and future in vitro approaches for drug metabolism.
@en
P2093
P304
P356
10.1016/S1056-8719(00)00110-6
P577
2000-07-01T00:00:00Z