RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution
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Determinants for hairpin formation in Tn10 transposition.HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationRag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexesOrdered assembly of the V(D)J synaptic complex ensures accurate recombinationThe RAG proteins in V(D)J recombination: more than just a nuclease.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseIdentification and characterization of a gain-of-function RAG-1 mutant.The bounty of RAGs: recombination signal complexes and reaction outcomes.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end ComplexesFull-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals.Both high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro.
P2860
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P2860
RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@ast
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@en
type
label
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@ast
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@en
prefLabel
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@ast
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@en
P2093
P2860
P356
P1476
RAG-1 and RAG-2-dependent asse ...... ination substrates in solution
@en
P2093
P2860
P304
P356
10.1128/MCB.17.12.6932
P407
P577
1997-12-01T00:00:00Z