A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase
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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic inventionCoupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiaePhosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complexPTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cyclePhosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformationPERK mediates cell-cycle exit during the mammalian unfolded protein responseRegulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylationGlycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationCalmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1A central domain of cyclin D1 mediates nuclear receptor corepressor activityUPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levelsTight function zonula occludens-3 regulates cyclin D1-dependent cell proliferationSomatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytesActivation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytesHsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinaseGenomic organization and evolutionary conservation of plant D-type cyclinsDisruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesisThe Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells.The Arabidopsis D-type cyclins CycD2 and CycD3 both interact in vivo with the PSTAIRE cyclin-dependent kinase Cdc2a but are differentially controlled.Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases.SNP-SNP interactions in breast cancer susceptibility.Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphomaA critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario.Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk.Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma.Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli.Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in miceUbiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators.Characterization of growth suppressive functions of a splice variant of cyclin D2.The heart: mostly postmitotic or mostly premitotic? Myocyte cell cycle, senescence, and quiescence.Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells.Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).
P2860
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P2860
A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@ast
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@en
type
label
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@ast
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@en
prefLabel
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@ast
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@en
P2860
P356
P1476
A dominant-negative cyclin D1 ...... ation by CDK-activating kinase
@en
P2093
P2860
P304
P356
10.1128/MCB.17.12.7362
P407
P577
1997-12-01T00:00:00Z