Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies

Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies

Item
http://www.wikidata.org/entity/Q36579186
Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics (CDx) Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged (ROS1-, RET-, AXL-, PDGFR-α-, NTRK1-) Non-Small Cell Lung Cancer Globally?TRKing down an old oncogene in a new era of targeted therapyPhase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors.Molecularly targeted therapies in non-small-cell lung cancer annual update 2014Cell cycle inhibitors for the treatment of NSCLC.Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Pharmacological cyclin dependent kinase inhibitors: Implications for colorectal cancer.Inhibitors of cyclin-dependent kinases as cancer therapeutics.Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Modeling and Targeting MYC Genes in Childhood Brain Tumors.Anti-tumour efficacy on glioma models of PHA-848125, a multi-kinase inhibitor able to cross the blood-brain barrier.Targeting the PTTG1 oncogene impairs proliferation and invasiveness of melanoma cells sensitive or with acquired resistance to the BRAF inhibitor dabrafenib.Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
P2860

Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies

Item
http://www.wikidata.org/entity/Q36579186
description
2011 nî lūn-bûn
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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2011年论文
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2011年论文
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name
Phase I study of the safety, t ...... th advanced solid malignancies
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Phase I study of the safety, t ...... th advanced solid malignancies
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Phase I study of the safety, t ...... th advanced solid malignancies
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Phase I study of the safety, t ...... th advanced solid malignancies
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Phase I study of the safety, t ...... th advanced solid malignancies
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Phase I study of the safety, t ...... th advanced solid malignancies
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Phase I study of the safety, t ...... th advanced solid malignancies
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P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P698
P932