Regulation of the cdk inhibitor p27 and its deregulation in cancer.
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Identification of HEXIM1 as a positive regulator of p5314-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machineryProtein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligaseCRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisNovel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functionsOncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancerRole of the F-box protein Skp2 in lymphomagenesisPhellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signallingSpy1 interacts with p27Kip1 to allow G1/S progressionRole of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradationTransforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancerThe role of the ubiquitination-proteasome pathway in breast cancer: use of mouse models for analyzing ubiquitination processesp27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosisDeregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerTGF-β cascade regulation by PPP1 and its interactors -impact on prostate cancer development and therapyMechanism of p27 Unfolding for CDK2 Reactivation.Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemiap27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysisHigh-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitorThe yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells.A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress.Information theoretical quantification of cooperativity in signalling complexes.Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma.Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.CARP is a potential tumor suppressor in gastric carcinoma and a single-nucleotide polymorphism in CARP gene might increase the risk of gastric carcinoma.Mitogenic regulation of p27(Kip1) gene is mediated by AP-1 transcription factors.Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cellsPAI-1 leads to G1-phase cell-cycle progression through cyclin D3/cdk4/6 upregulationRole of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration.Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia.Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cellsRole of phosphorylation in progesterone receptor signaling and specificity
P2860
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P2860
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@ast
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@en
type
label
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@ast
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@en
prefLabel
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@ast
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@en
P1476
Regulation of the cdk inhibitor p27 and its deregulation in cancer.
@en
P2093
Slingerland J
P356
10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.3.CO;2-9
P577
2000-04-01T00:00:00Z