The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line.
about
Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylationInteraction of NF-E2 in the human beta-globin locus control region before chromatin remodelingTwo domains of the human bZIP transcription factor TCF11 are necessary for transactivationRegulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cellsDNA bending and wrapping around RNA polymerase: a "revolutionary" model describing transcriptional mechanisms.The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceLoading of DNA-binding factors to an erythroid enhancer.USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesisActivation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter.Nuclear relocation of a transactivator subunit precedes target gene activation.Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locusLineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter.Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoterMitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.MPN patients harbor recurrent truncating mutations in transcription factor NF-E2Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivoGenetic dissection of hTAF(II)130 defines a hydrophobic surface required for interaction with glutamine-rich activators.The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.Cell-cycle specific association of transcription factors and RNA polymerase ii with the human β-globin gene locusDisruption of the mechanism of long range activation within the human alpha-globin complex.Erythroid gene suppression by NF-kappa B.Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells.The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters.Understanding fetal globin gene expression: a step towards effective HbF reactivation in haemoglobinopathies.
P2860
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P2860
The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The activation domain of the e ...... oci in an erythroid cell line.
@ast
The activation domain of the e ...... oci in an erythroid cell line.
@en
type
label
The activation domain of the e ...... oci in an erythroid cell line.
@ast
The activation domain of the e ...... oci in an erythroid cell line.
@en
prefLabel
The activation domain of the e ...... oci in an erythroid cell line.
@ast
The activation domain of the e ...... oci in an erythroid cell line.
@en
P2093
P2860
P356
P1476
The activation domain of the e ...... oci in an erythroid cell line.
@en
P2093
P2860
P304
10051-10056
P356
10.1073/PNAS.94.19.10051
P407
P577
1997-09-01T00:00:00Z