Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
about
Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cellsE3 ubiquitin ligase COP1 regulates the stability and functions of MTA1Gene knockout of Acc2 has little effect on body weight, fat mass, or food intakeChronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolismCrystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanismMolecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of FlavonoidsMetabolomics applied to the pancreatic isletStructure and function of biotin-dependent carboxylasesUncovering genomic causes of co-morbidity in epilepsy: gene-driven phenotypic characterization of rare microdeletionsProtein biotinylation visualized by a complex structure of biotin protein ligase with a substrateA different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydimCrystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit of Streptomyces coelicolor ,Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxadenGenetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA CarboxylaseDistinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection.Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.Identifying essential genes in bacterial metabolic networks with machine learning methodsRecombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy.Human acetyl-CoA carboxylase 2 expressed in silkworm Bombyx mori exhibits posttranslational biotinylation and phosphorylation.Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells.Acetylated and propionated derivatives of swertiamarin have anti-adipogenic effects.Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolismSingle-site mutations in the carboxyltransferase domain of plastid acetyl-CoA carboxylase confer resistance to grass-specific herbicides.Trypanosoma brucei: inhibition of acetyl-CoA carboxylase by haloxyfopRepression of endometrial tumor growth by targeting SREBP1 and lipogenesisAcetyl-CoA carboxylase regulates global histone acetylation.Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death.Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fatAcetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in miceMechanism of metamifop inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in Echinochloa crus-galliSREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancerInhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.
P2860
Q24302032-DCD0D4C5-51F8-4CBC-95FB-49469F608CE8Q24322010-98F9821F-F5DF-46A5-B8FE-A3713209D1BFQ24622227-A80A9699-6FEE-48F7-92BF-5C71E57189CAQ24653884-EAAE2EBD-352B-4EB3-9947-5219720B6A03Q24657832-621D9BB1-1A84-465B-AA5B-B3F6CA81CF63Q26752387-917598C1-206B-49CC-B900-BE242424C3EBQ26824852-78A75EF1-4000-4BC5-B866-07FA26E2588CQ26851762-4DB21D6E-64A9-4089-9F19-8715C72F16A9Q27324674-3E688F08-2A68-4369-8F2D-A58FEEE576E7Q27650176-48222F49-4384-47F5-ADE7-59FC5F2D92CDQ27658275-400AA853-F640-4E60-BE8F-5A0284A5DF98Q27663890-029712C2-4532-4156-B3E5-63EFD0E3BFEBQ27666211-9ADC8A78-6516-4A5E-95C3-C14826B86D50Q28658083-A3A99890-CD31-44D8-BF61-644731405F36Q28817514-0D3E01D9-E732-4261-9C8D-98DE38A0BFE6Q30276614-CC827798-FC0A-4A9D-868A-D9A26E1C3228Q30278693-AF2AB13B-F4E9-49C5-A83B-38337E212791Q30651985-1D4D8BAF-4C2B-4005-A48E-3275583283F0Q33570986-83F640BA-7A61-4569-9A8A-7A35CDD08A04Q33571309-9D70F82D-7B0C-4253-8B55-0CF49D9ED3CEQ33675261-3F12C49C-BE52-4111-8571-52E46EF6870EQ34175977-30CCD583-DF57-48FB-AEE7-CB2E01976A3AQ34397545-9F4BCC83-7B4F-4E8D-879C-7BEB75BB0ECBQ34483548-C7326DBB-4346-4B2E-851D-D76F48CFDF0EQ34509083-A8224172-C42E-4680-AABC-2177F241CBEEQ34543236-7AAE837E-CCB5-47EC-883B-B9829E3BDCF6Q34796433-27631698-313D-4BD8-9883-130F4507FF5AQ35141658-A0956DDA-7460-4175-B901-5E9A61344F27Q35645591-FC36E656-FA34-42CF-9FC2-9D206AE43788Q35690720-C76C156E-1CF0-4403-A019-A775F17FC4FDQ36059708-F0C4A872-685F-400E-AA1F-4A79267EE66CQ36078858-80C513E7-D967-46F9-AA51-633628FE874CQ36135360-7BEC1AEF-E038-4339-BA7D-689E8C4CEC53Q36263068-E6F875EE-11D4-4A2D-8165-8231377D968AQ36406416-95F4D7FD-085F-4E86-9BC9-64CE62E8FF2AQ36770743-855D8133-3D83-4476-9862-BAC6A92E71A2Q36881816-866FA9BE-0EC1-4143-9941-400D98F7A958Q37282360-E234FFFB-9E15-4890-9940-D0FA41DF7269Q37289439-8753B8E3-32BD-41FC-92A0-AF680F41B153Q37317840-21BA3B35-98D2-4D77-B6BF-333BBC11BCDB
P2860
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@ast
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@en
type
label
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@ast
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@en
prefLabel
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@ast
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@en
P2860
P356
P1476
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery.
@en
P2093
H James Harwood
Liang Tong
P2860
P304
P356
10.1002/JCB.21077
P577
2006-12-01T00:00:00Z