Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling. - Wikidata - awgldk - TriplyDB

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

http://www.wikidata.org/entity/Q36598338

about

SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway "Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer.New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation.Senataxin controls meiotic silencing through ATR activation and chromatin remodeling.Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.Insights into dynamic mitotic chromatin organization through the NIMA kinase suppressor SonC, a chromatin-associated protein involved in the DNA damage response.Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26.Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration.Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion.Replication checkpoint: tuning and coordination of replication forks in s phase.NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between α-Adducin and Myosin X.Mitotic Regulation by NEK Kinase Networks.Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.Preserving Salivary Gland Physiology against Genotoxic Damage - The Tousled Way.ATR activation at DNA DSBs

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P2860

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

http://www.wikidata.org/entity/Q36598338

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

@zh-cn

name

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@ast

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@en

type

label

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@ast

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@en

prefLabel

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@ast

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@en

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P356

PNAS.1217781110

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

@en

P2093

Chu Kwen Ho

http://www.w3.org/2001/XMLSchema#string

Jian Ouyang

http://www.w3.org/2001/XMLSchema#string

Lee Zou

http://www.w3.org/2001/XMLSchema#string

Shizhou Liu

http://www.w3.org/2001/XMLSchema#string

P2860

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

NEK1 mutations cause short-rib polydactyly syndrome type majewski

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice

P304

2175-2180

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scholarly article

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10.1073/PNAS.1217781110

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6

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110

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