NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
about
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsNek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageThe Roles of NDR Protein Kinases in Hippo SignallingPerspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancerNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Checkpoint kinase 1 in DNA damage response and cell cycle regulationRoles of Chk1 in cell biology and cancer therapyATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeresDNA damage response genes and the development of cancer metastasisLoss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging AgentsThe role of Cdc25A in the regulation of cell proliferation and apoptosisMiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A.Exploiting polypharmacology for drug target deconvolution"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinasesP27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseNovel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instabilityA human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosisNew interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicingEvolutionary emergence of a novel splice variant with an opposite effect on the cell cycle.SCF ubiquitin ligases in the maintenance of genome stability.Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.The ATR barrier to replication-born DNA damage.Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.Insights into dynamic mitotic chromatin organization through the NIMA kinase suppressor SonC, a chromatin-associated protein involved in the DNA damage response.CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.ATR: a master conductor of cellular responses to DNA replication stress.Beyond ATM: the protein kinase landscape of the DNA damage response.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.Checkpoint control and cancer.CRL Ubiquitin Ligases and DNA Damage Response.Cell cycle regulation by the NEK family of protein kinases.Pathways for genome integrity in G2 phase of the cell cycle.Structure, function, and evolution of plant NIMA-related kinases: implication for phosphorylation-dependent microtubule regulation.
P2860
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P2860
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@ast
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en-gb
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@nl
type
label
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@ast
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en-gb
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@nl
prefLabel
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@ast
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en-gb
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@nl
P2093
P2860
P3181
P356
P1433
P1476
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
@en
P2093
Claus Storgaard Sørensen
Ditte Kjaersgaard Klein
Marina Melixetian
P2860
P2888
P304
P3181
P356
10.1038/NCB1969
P407
P577
2009-10-01T00:00:00Z
P5875
P6179
1031949135