The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy
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Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamicsStructure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,Catalytic mechanism of a mammalian Rab{middle dot}RabGAP complex in atomic detailSurface-Attached Polyhistidine-Tag Proteins Characterized by FTIR Difference SpectroscopyDefying the activity-stability trade-off in enzymes: taking advantage of entropy to enhance activity and thermostability.(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP HydrolysisA novel Golgi retention signal RPWS for tumor suppressor UBIAD1.Phosphate vibrations probe local electric fields and hydration in biomoleculesEfforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductaseA modified infrared spectrometer with high time resolution and its application for investigating fast conformational changes of the GTPase Ras.Competing pathways in the photo-Favorskii rearrangement and release of esters: studies on fluorinated p-hydroxyphenacyl-caged GABA and glutamate phototriggers.Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Exceptionally large entropy contributions enable the high rates of GTP hydrolysis on the ribosome.Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations.Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy.The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway.Mechanism of the intrinsic arginine finger in heterotrimeric G proteins.The dynamics of the catalytic site in small GTPases, variations on a common motif.Ras activation revisited: role of GEF and GAP systems.Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein functionThe small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.Protein Regulation in Signal Transduction.Unravelling the mechanism of dual-specificity GAPs.Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP.Mechanism of crystalline self-assembly in aqueous medium: a combined cryo-TEM/kinetic study.Stereochemically probing the photo-Favorskii rearrangement: a mechanistic investigationTime-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle.The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations.Photorelease of phosphates: Mild methods for protecting phosphate derivatives.Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions.Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis.The cation-dependent G-proteins: in a class of their own.Importance of an Orchestrate Participation of Each Individual Residue Present at a Catalytic Site.Microhydrated dihydrogen phosphate clusters probed by gas phase vibrational spectroscopy and first principles calculations.Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A.
P2860
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P2860
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The GAP arginine finger moveme ...... creases the activation entropy
@ast
The GAP arginine finger moveme ...... creases the activation entropy
@en
type
label
The GAP arginine finger moveme ...... creases the activation entropy
@ast
The GAP arginine finger moveme ...... creases the activation entropy
@en
prefLabel
The GAP arginine finger moveme ...... creases the activation entropy
@ast
The GAP arginine finger moveme ...... creases the activation entropy
@en
P2860
P50
P356
P1476
The GAP arginine finger moveme ...... creases the activation entropy
@en
P2093
Angela Kallenbach
P2860
P304
P356
10.1073/PNAS.0712095105
P407
P577
2008-04-23T00:00:00Z