Temozolomide induces senescence but not apoptosis in human melanoma cells.
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Small molecule compounds that induce cellular senescenceThe combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53A New Epigenetic Mechanism of Temozolomide Action in Glioma CellsQuercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.Selenium Inhibits Metastasis of Murine Melanoma Cells through the Induction of Cell Cycle Arrest and Cell Death.Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models.P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferationMGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome.Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells.Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapyChemoresistance of glioblastoma cancer stem cells--much more complex than expected.Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis.NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug.Inhibition of Human Adrenocortical Cancer Cell Growth by Temozolomide in Vitro and the Role of the MGMT Gene.A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems.Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.Advances in melanoma senescence and potential clinical application.In Vitro Radiosensitizing Effects of Temozolomide on U87MG Cell Lines of Human Glioblastoma Multiforme.B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells.Mechanism of temozolomide-induced antitumour effects on glioma cells.Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma.Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation.5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-δCarnitine-induced senescence in glioblastoma cells.Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1.Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway.Altholactone induces apoptotic cell death in human colorectal cancer cells.
P2860
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P2860
Temozolomide induces senescence but not apoptosis in human melanoma cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Temozolomide induces senescence but not apoptosis in human melanoma cells.
@ast
Temozolomide induces senescence but not apoptosis in human melanoma cells.
@en
type
label
Temozolomide induces senescence but not apoptosis in human melanoma cells.
@ast
Temozolomide induces senescence but not apoptosis in human melanoma cells.
@en
prefLabel
Temozolomide induces senescence but not apoptosis in human melanoma cells.
@ast
Temozolomide induces senescence but not apoptosis in human melanoma cells.
@en
P2093
P2860
P356
P1476
Temozolomide induces senescence but not apoptosis in human melanoma cells
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.BJC.6604017
P407
P577
2007-10-30T00:00:00Z