Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. - Wikidata - awgldk - TriplyDB

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

http://www.wikidata.org/entity/Q36614722

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A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor Serine/threonine protein phosphatases Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration Calcineurin/Nfat signaling is required for perinatal lung maturation and function Treatment of hippocampal neurons with cyclosporin A results in calcium overload and apoptosis which are independent on NMDA receptor activation Cain, a novel physiologic protein inhibitor of calcineurin Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia.FK506 and the role of the immunophilin FKBP-52 in nerve regeneration.Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity.Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector.Cyclophilins and their possible role in the stress response.Calcineurin links Ca2+ dysregulation with brain aging Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders.Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondria Neuroimmunophilins: novel neuroprotective and neuroregenerative targets.Neuropsychiatric complications of liver and other solid organ transplantation.NMDA receptor and neonatal hypoxic brain injury.Potential of immunosuppressive agents in cerebral ischaemia.Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia Mechanisms of dendritic spine remodeling in a rat model of traumatic brain injury.Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.Nitric oxide: foe or friend to the injured brain?The mitochondrial permeability transition in neurologic disease Tacrolimus in the treatment of idiopathic nephrotic syndrome.Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.Calcineurin inhibition enhances motor neuron survival following injury Tissue engineered constructs for peripheral nerve surgery.Clinical strategies to enhance nerve regeneration in composite tissue allotransplantation.Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process.Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat.Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones.Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.Nitric oxide: role in neurotoxicity.Endogenous nitric oxide in cardiovascular disease and transplantation.Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo.Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release.Increased calcineurin expression after pilocarpine-induced status epilepticus is associated with brain focal edema and astrogliosis.Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms.

P2860

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P2860

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

http://www.wikidata.org/entity/Q36614722

description

1993 nî lūn-bûn

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年论文

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1993年论文

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1993年论文

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name

Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

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Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

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type

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Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

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Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

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Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

@ast

Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Immunosuppressant FK506 enhanc ...... ainst glutamate neurotoxicity.

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P2093

G R Uhl

http://www.w3.org/2001/XMLSchema#string

J L Dinerman

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J P Steiner

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T M Dawson

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V L Dawson

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P2860

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13

Nitric oxide: physiology, pathophysiology, and pharmacology

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites

Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

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21

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90

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Solomon Halbert Snyder

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15505458

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7694293

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P921

immunosuppression

phosphorylation

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47661

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