Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexesCalcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloidesCyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiaeCyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionCryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcomeThe immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target proteinGenetic and genomic architecture of the evolution of resistance to antifungal drug combinationsCalcineurin Targets Involved in Stress Survival and Fungal VirulenceImmunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytesImmunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurinGene activation by interaction of an inhibitor with a cytoplasmic signaling protein.Calcineurin is essential for survival during membrane stress in Candida albicans.Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals.Signaling cascades as drug targets in model and pathogenic fungi.Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain.Regulator of calcineurin 1 mediates pathological vascular wall remodelingCalcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.Calcineurin signaling in the heart: The importance of time and place.Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformansCalcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling.Rapamycin specifically interferes with the developmental response of fission yeast to starvation.Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressantsElucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.Calcineurin is required for virulence of Cryptococcus neoformans.FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia
P2860
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P2860
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Targets of immunophilin-immuno ...... rved regions of calcineurin A.
@en
type
label
Targets of immunophilin-immuno ...... rved regions of calcineurin A.
@en
prefLabel
Targets of immunophilin-immuno ...... rved regions of calcineurin A.
@en
P2093
P2860
P1433
P1476
Targets of immunophilin-immuno ...... rved regions of calcineurin A.
@en
P2093
P2860
P304
P407
P577
1995-06-01T00:00:00Z