Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain
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Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshateLactosylceramide contributes to mitochondrial dysfunction in diabetesCeramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemiaGlucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans.Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsyCeramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse modelsHepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis.Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signalingAlkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage responseIn vivo study of hepatic oxidative stress and mitochondrial function in rabbits with severe hypotension after propofol prolonged infusionKCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stressEffects of traditional Chinese medicine on rats with Type II diabetes induced by high-fat diet and streptozotocin: a urine metabonomic studyProtection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalizationAltering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalizationAlkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.Cadmium and cellular signaling cascades: interactions between cell death and survival pathways.The importance of sphingolipids and reactive oxygen species in cardiovascular development.Sphingolipids and mitochondrial apoptosis.Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity.Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect.Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson’s disease.Mitochondrial tRNA mutation with high-salt stimulation on cardiac damage: underlying mechanism associated with change of Bax and VDAC.Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels.LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.Development of pheochromocytoma in ceramide synthase 2 null mice.Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection.Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills.Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis.Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders.Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer.Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice.A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.
P2860
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P2860
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Ablation of ceramide synthase ...... itochondrial respiratory chain
@ast
Ablation of ceramide synthase ...... itochondrial respiratory chain
@en
type
label
Ablation of ceramide synthase ...... itochondrial respiratory chain
@ast
Ablation of ceramide synthase ...... itochondrial respiratory chain
@en
prefLabel
Ablation of ceramide synthase ...... itochondrial respiratory chain
@ast
Ablation of ceramide synthase ...... itochondrial respiratory chain
@en
P2093
P2860
P356
P1476
Ablation of ceramide synthase ...... itochondrial respiratory chain
@en
P2093
Alfred H Merrill
Avigdor Scherz
Aviram Kogot-Levin
Hila Zigdon
Joo-Won Park
Ruth Goldschmidt
Samuel Kelly
Yael Pewzner-Jung
P2860
P304
P356
10.1074/JBC.M112.402719
P407
P577
2013-01-02T00:00:00Z