Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.
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Inactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancyAnion transport in heartFunctional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domainsStructure and function of the cystic fibrosis transmembrane conductance regulator.Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.Cystic fibrosis transmembrane conductance regulator (CFTR) anion binding as a probe of the poreCFTR: a cysteine at position 338 in TM6 senses a positive electrostatic potential in the pore.The block of CFTR by scorpion venom is state-dependentCFTR: Ligand exchange between a permeant anion ([Au(CN)2]-) and an engineered cysteine (T338C) blocks the pore.Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysisCystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Insight in eukaryotic ABC transporter function by mutation analysis.Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated stateRegulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptorSevered molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain.CFTR: covalent modification of cysteine-substituted channels expressed in Xenopus oocytes shows that activation is due to the opening of channels resident in the plasma membranePositioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulatorDeep resequencing of CFTR in 762 F508del homozygotes reveals clusters of non-coding variants associated with cystic fibrosis disease traits.Mechanism of dysfunction of two nucleotide binding domain mutations in cystic fibrosis transmembrane conductance regulator that are associated with pancreatic sufficiency.CFTR pharmacology.Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules.Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel.Pyrophosphate stimulates wild-type and mutant cystic fibrosis transmembrane conductance regulator Cl- channels.CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin.Genistein potentiates wild-type and delta F508-CFTR channel activity.Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein.Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation.Hydrolytic and nonhydrolytic interactions in the ATP regulation of CFTR Cl- conductance.Novel subunit composition of a renal epithelial KATP channel.Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator.Pharmacology of CFTR chloride channel activity.Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.
P2860
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P2860
Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Functional roles of the nucleo ...... embrane conductance regulator.
@ast
Functional roles of the nucleo ...... embrane conductance regulator.
@en
type
label
Functional roles of the nucleo ...... embrane conductance regulator.
@ast
Functional roles of the nucleo ...... embrane conductance regulator.
@en
prefLabel
Functional roles of the nucleo ...... embrane conductance regulator.
@ast
Functional roles of the nucleo ...... embrane conductance regulator.
@en
P2093
P2860
P356
P1476
Functional roles of the nucleo ...... embrane conductance regulator.
@en
P2093
D C Dawson
D J Wilkinson
F S Collins
M K Mansoura
P2860
P304
P356
10.1073/PNAS.90.21.9963
P407
P577
1993-11-01T00:00:00Z