Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
about
A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetesThe Nucleotide-Binding Sites of SUR1: A Mechanistic ModelTargeting microglial K(ATP) channels to treat neurodegenerative diseases: a mitochondrial issueBoth G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.Potassium channel regulation.Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAATP interaction with the open state of the K(ATP) channel.Interaction of stilbene disulphonates with cloned K(ATP) channelsNADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretionProximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channelsEngineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutationsAltered functional properties of KATP channel conferred by a novel splice variant of SUR1.ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.Impact of disease-causing SUR1 mutations on the KATP channel subunit interface probed with a rhodamine protection assay.Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction.Inward rectification in KATP channels: a pH switch in the pore.Molecular determinants of KATP channel inhibition by ATP.Potassium channel openers require ATP to bind to and act through sulfonylurea receptorsHuman K(ATP) channelopathies: diseases of metabolic homeostasis.Controlling potassium channel activities: Interplay between the membrane and intracellular factors.Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.KATP channels gated by intracellular nucleotides and phospholipids.Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide bindingThe kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATPConcerted gating mechanism underlying KATP channel inhibition by ATP.Genetic heterogeneity in familial hyperinsulinism.Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy.N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2How azide inhibits ATP hydrolysis by the F-ATPases.The molecular basis of the specificity of action of K(ATP) channel openers.K(ATP) channels and insulin secretion disorders.Diabetes and insulin secretion: whither KATP?Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamideExercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation.Direct interaction of Na-azide with the KATP channel.Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetesMuscle KATP channels: recent insights to energy sensing and myoprotectionN-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits.Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia.
P2860
Q24656945-C6717FA0-F7F8-4754-855F-62CD91AFA15BQ26774807-9494806A-3939-45E4-AF7D-6F1311C2F8A8Q26852041-4965E8C8-1FCD-4731-9645-2B5D28EBC132Q27865205-21D82F12-3B9E-4294-9BE2-2ADC6F4115B0Q28181292-0DA30F95-D628-4817-8982-9CF27A193169Q28284068-93A4FD7A-CAC1-4952-81EF-9DBB0EEB7135Q28346280-05549667-B826-4145-A74E-E1171544635DQ28354142-D4AEAA9B-BEB9-43A8-B645-A95CEA5F70FEQ28371866-4652B787-D17D-4CE9-AA96-11FE07A625A6Q28572793-4010D37D-68A2-4D94-8C51-432AD2B43D3DQ28941209-3CE6CDD6-1662-4C73-B152-ED517CB6491AQ30821155-E94937A9-9C2B-4725-A38A-ADBD28C91461Q31685657-C3812073-CCAC-4CC8-96FB-4393C6938FE5Q33661454-96E2D541-55EC-4605-8F7B-5B351CC81BA2Q33783529-8871A18C-94BB-45B5-B76D-D7D21B2C828FQ33852328-5668592C-A80F-4A65-85CF-50E49EB6879CQ33888944-89E8062C-FC10-4FCF-B2AA-B61FB854A3E6Q33889545-74928CF6-E65F-414B-8C10-09B730E84674Q33906965-D17DFAF2-13CF-403B-9120-834AE9C1FED0Q33944209-25061171-2C22-4D28-B181-36598C8107D8Q34014483-719DDBE5-4829-4B32-BDB6-3915FC3614C5Q34039980-66513D5C-9F97-490D-91DD-D495B1321CDBQ34079244-1FBEC307-4ED0-4DD9-830D-E7D23C188243Q34172980-2779A9CE-7779-46BE-B053-6029EB4466F8Q34173659-6AE1CC39-A1BB-4C2C-BF9D-CD2FDCA1A472Q34185246-29D739E2-0D12-4635-A0F7-01D2BD42A194Q34470870-1EDBBC84-51DF-4BB3-9E55-DE8962831514Q34502736-BC9360FE-BC79-4833-B483-895EB9524894Q34618893-44692E5F-849B-4836-AB1F-2313C391FF86Q34637621-76DA7FE6-1D43-4B00-A0B6-09E3BFCE7A0FQ34685091-EC9BA5EC-8601-4309-A04C-BD316C3303AAQ34731579-BCC1B5AA-0F79-4AB5-A437-5C373185D270Q34778263-D6DCAD2C-A24E-4498-A6D0-C8FC9E35FA8AQ34986893-35934BF2-BE4D-44D7-8D74-8B7CFC97304FQ35011954-663583C4-2A9C-4E19-BFA6-1CFE3BF61926Q35042895-3A50859F-E66A-49C1-A77F-6F29AD178527Q35043410-F652BF2B-5E97-4997-87E8-6CA7628690DFQ35076166-F52A6BE3-F00E-48ED-BC4E-A467DBC8FFACQ35208854-87F09423-0194-43FD-88B1-58B7D13E2BFEQ35592742-82538FA9-8007-4CC0-BAE0-E9D29E8904AD
P2860
Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@ast
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@en
type
label
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@ast
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@en
prefLabel
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@ast
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@en
P2093
P2860
P356
P1476
Regulation of KATP channel act ...... s of the sulfonylurea receptor
@en
P2093
P2860
P304
P356
10.1085/JGP.110.6.643
P577
1997-12-01T00:00:00Z