A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats.
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De novo synthesis of VP16 coordinates the exit from HSV latency in vivo.Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicityGenetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection.Towards an understanding of the herpes simplex virus type 1 latency-reactivation cyclePseudotyping of glycoprotein D-deficient herpes simplex virus type 1 with vesicular stomatitis virus glycoprotein G enables mutant virus attachment and entry.Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latencyHerpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latencyAnalysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same regionHerpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured ratsA herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applicationsA gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levelsHistone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cellsRegions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity.Experimental investigation of herpes simplex virus latencySpecific histone tail modification and not DNA methylation is a determinant of herpes simplex virus type 1 latent gene expression.Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcriptsTwo overlapping transcription units which extend across the L-S junction of herpes simplex virus type 1.Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latencyIdentification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16.A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo.In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcriptThe herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells.Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structureUtilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system.The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosineThe latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpesExpression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigsIncreased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript.The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latencyTwo open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latencyHerpes vector-mediated gene transfer in the treatment of chronic pain
P2860
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P2860
A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A novel latency-active promote ...... us type 1 UL flanking repeats.
@ast
A novel latency-active promote ...... us type 1 UL flanking repeats.
@en
type
label
A novel latency-active promote ...... us type 1 UL flanking repeats.
@ast
A novel latency-active promote ...... us type 1 UL flanking repeats.
@en
prefLabel
A novel latency-active promote ...... us type 1 UL flanking repeats.
@ast
A novel latency-active promote ...... us type 1 UL flanking repeats.
@en
P2093
P2860
P1433
P1476
A novel latency-active promote ...... rus type 1 UL flanking repeats
@en
P2093
J C Glorioso
L R Sternberg
R L Hendricks
S E Straus
P2860
P304
P407
P577
1994-04-01T00:00:00Z