The action of selective CRAC channel blockers is affected by the Orai pore geometry. - Wikidata - awgldk - TriplyDB

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

http://www.wikidata.org/entity/Q36632593

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SOCE and cancer: Recent progress and new perspectives The role of Ca2+ in the pathophysiology of pancreatitis Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.ORAI1 calcium channel orchestrates skin homeostasis.Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane.Store-Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression.Epithelial-mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration Ion channels in innate and adaptive immunity Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain.Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells Molecular pharmacology of store-operated CRAC channels.Ca(2+) release-activated Ca(2+) channel inhibitors.Store-operated CRAC channel inhibitors: opportunities and challenges.Targeting calcium signaling in cancer therapy.Calcium Channels in Vascular Smooth Muscle.Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells.Store-operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle.Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway.Glu106 targeted inhibitors of ORAI1 as potential Ca2+ release-activated Ca2+ (CRAC) channel blockers - molecular modeling and docking studies.Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors.Store-Operated Calcium Channels.High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts.Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry.Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.

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P2860

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

http://www.wikidata.org/entity/Q36632593

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

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The action of selective CRAC channel blockers is affected by the Orai pore geometry.

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type

label

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

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The action of selective CRAC channel blockers is affected by the Orai pore geometry.

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prefLabel

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

@ast

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

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J.CECA.2012.11.005

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The action of selective CRAC channel blockers is affected by the Orai pore geometry.

@en

P2093

Christoph Romanin

http://www.w3.org/2001/XMLSchema#string

David House

http://www.w3.org/2001/XMLSchema#string

Isabella Derler

http://www.w3.org/2001/XMLSchema#string

Malcolm Begg

http://www.w3.org/2001/XMLSchema#string

Maria Christine Riedl

http://www.w3.org/2001/XMLSchema#string

Peter Heftberger

http://www.w3.org/2001/XMLSchema#string

Rainer Schindl

http://www.w3.org/2001/XMLSchema#string

Reinhard Fritsch

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P2860

Orai1 and STIM reconstitute store-operated calcium channel function

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

Orai1 is an essential pore subunit of the CRAC channel

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels

K+ channels as targets for specific immunomodulation

TRP channel activation by reversible covalent modification

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Orai1 calcium channels in the vasculature

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139-151

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10.1016/J.CECA.2012.11.005

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2

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