Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
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A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissueEpigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated HepatocarcinogenesisAMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetesInsulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start siteHistone deacetylase inhibitor pracinostat in doublet therapy: a unique strategy to improve therapeutic efficacy and to tackle herculean cancer chemoresistance.Peroxisome proliferator-activated receptor gamma coactivator-1 alpha acts as a tumor suppressor in hepatocellular carcinoma.Transcriptional coregulators: fine-tuning metabolism.The class I histone deacetylase inhibitor MS-275 prevents pancreatic beta cell death induced by palmitate.Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function.β-hydroxybutyrate: much more than a metaboliteSodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioningConditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure.The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging.Subcellular Localization of Class I Histone Deacetylases in the Developing Xenopus tectum.Improving insulin sensitivity with HDAC inhibitorHistone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation.Anti-Inflammatory Effect of Spirulina platensis in Macrophages Is Beneficial for Adipocyte Differentiation and Maturation by Inhibiting Nuclear Factor-κB Pathway in 3T3-L1 Adipocytes.The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.Anti-Inflammatory Effects of Spirulina platensis Extract via the Modulation of Histone Deacetylases.Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions.HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy.Histone deacetylase inhibition regulates miR-449a levels in skeletal muscle cells.Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetesMolecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte functionLT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.Systemic Regulators of Skeletal Muscle Regeneration in Obesity.Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link.Epigenetic regulation and heart failure.Exercise and the Skeletal Muscle Epigenome.Crosstalk between adipokines and myokines in fat browning.Histone deacetylase inhibitor givinostat: the small-molecule with promising activity against therapeutically challenging haematological malignancies.Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells.Epigenetic Regulation of the Thermogenic Adipose Program.Epigenomic and transcriptional control of insulin resistance.Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus.HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browningStrategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance.Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases.
P2860
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P2860
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Inhibition of class I histone ...... etal muscle and adipose tissue
@ast
Inhibition of class I histone ...... etal muscle and adipose tissue
@en
type
label
Inhibition of class I histone ...... etal muscle and adipose tissue
@ast
Inhibition of class I histone ...... etal muscle and adipose tissue
@en
prefLabel
Inhibition of class I histone ...... etal muscle and adipose tissue
@ast
Inhibition of class I histone ...... etal muscle and adipose tissue
@en
P2093
P2860
P50
P356
P1433
P1476
Inhibition of class I histone ...... etal muscle and adipose tissue
@en
P2093
Alessandra Ferrari
Andrea Galmozzi
Cristina Godio
Donatella Caruso
Elise Gers
Enrique Saez
Uliano Guerrini
P2860
P304
P356
10.2337/DB12-0548
P407
P50
P577
2012-10-15T00:00:00Z