about
Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cyclesCrystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug designSynthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activityA multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liverSite-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.Linking epigenetics to lipid metabolism: focus on histone deacetylases.Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signalsLXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system.Transcriptional regulatory logic of the diurnal cycle in the mouse liver.Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissueBile acids and their signaling pathways: eclectic regulators of diverse cellular functions.The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.Bile acids and gene regulation: from nuclear receptors to chromatin.LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.Sterol-protein interactions in cholesterol and bile acid synthesis.Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice.When food meets man: the contribution of epigenetics to health.RXRs: collegial partners.Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions.HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browningStructural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.Inflammatory serum proteome pattern in mice fed a high-fat diet.Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.Hemicentin 1 influences podocyte dynamic changes in glomerular diseases.Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total DeletionLack of Adipocytes Alters Hematopoiesis in Lipodystrophic MiceRenal mineralocorticoid receptor expression is reduced in lipoatrophyAnti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissuePPARγ Controls Ectopic Adipogenesis and Cross-Talks with Myogenesis During Skeletal Muscle RegenerationSystemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Federica Gilardi
@ast
Federica Gilardi
@en
Federica Gilardi
@es
Federica Gilardi
@nl
type
label
Federica Gilardi
@ast
Federica Gilardi
@en
Federica Gilardi
@es
Federica Gilardi
@nl
prefLabel
Federica Gilardi
@ast
Federica Gilardi
@en
Federica Gilardi
@es
Federica Gilardi
@nl
P106
P21
P31
P496
0000-0001-5421-2779