Atypical cytochrome p450 kinetics: implications for drug discovery.
about
A novel type of allosteric regulation: functional cooperativity in monomeric proteinsPotent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 CatalysisEngineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationModulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resinPhysiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in RatsDioxygenases catalyze O-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy.Substrate binding to cytochromes P450.Cooperative properties of cytochromes P450.Herb-drug interactions: challenges and opportunities for improved predictions.Substrate inhibition kinetics in drug metabolism reactions.Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsEvidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam.Effects of some commonly used Saudi folk herbal medications on the metabolic activity of CYP2C9 in human liver microsomes.Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene.Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences.
P2860
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P2860
Atypical cytochrome p450 kinetics: implications for drug discovery.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Atypical cytochrome p450 kinetics: implications for drug discovery.
@ast
Atypical cytochrome p450 kinetics: implications for drug discovery.
@en
type
label
Atypical cytochrome p450 kinetics: implications for drug discovery.
@ast
Atypical cytochrome p450 kinetics: implications for drug discovery.
@en
prefLabel
Atypical cytochrome p450 kinetics: implications for drug discovery.
@ast
Atypical cytochrome p450 kinetics: implications for drug discovery.
@en
P1433
P1476
Atypical cytochrome p450 kinetics: implications for drug discovery.
@en
P2093
Timothy S Tracy
P304
P356
10.2165/00126839-200607060-00004
P577
2006-01-01T00:00:00Z