Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.
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Viral evolution and escape during acute HIV-1 infectionInterleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersRole of HLA Adaptation in HIV EvolutionMechanisms of HIV protein degradation into epitopes: implications for vaccine designImmune activation and paediatric HIV-1 disease outcomeMutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infectionsHuman leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationshipsInfluence of HAART on alternative reading frame immune responses over the course of HIV-1 infectionSelection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South AfricaHIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine developmentDefining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applications.CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisWhole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection.Modelling the evolution and spread of HIV immune escape mutantsComplexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infectionReplicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rateAdaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.HLA-associated immune pressure on Gag protein in CRF01_AE-infected individuals and its association with plasma viral load.CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionHIV-1 vaccine development after STEP.Timing of immune escape linked to success or failure of vaccination.Quantifying the impact of human immunodeficiency virus-1 escape from cytotoxic T-lymphocytes.HIV-1 Transmission, Replication Fitness and Disease Progression.The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.Dynamics and timing of in vivo mutations at Gag residue 242 during primary HIV-1 subtype C infection.Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virusHIV RNA level in early infection is predicted by viral load in the transmission source.Impaired replication capacity of acute/early viruses in persons who become HIV controllers.The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.Immunity to HIV in Early LifeVirulence and pathogenesis of HIV-1 infection: an evolutionary perspectiveAntenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting.Changes in function of HIV-specific T-cell responses with increasing time from infection.Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parametersImpact of MHC class I diversity on immune control of immunodeficiency virus replication.Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation.Impact of HLA selection pressure on HIV fitness at a population level in Mexico and Barbados.Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infectionHLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function
P2860
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P2860
Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@ast
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@en
type
label
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@ast
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@en
prefLabel
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@ast
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@en
P2093
P2860
P50
P356
P1476
Transmission of HIV-1 Gag immu ...... ral load in linked recipients.
@en
P2093
Anju Bansal
Cynthia A Derdeyn
David Heckerman
Eric Hunter
Jonathan M Carlson
Joseph Mulenga
Karina Yusim
Paul A Goepfert
Paul Farmer
Philip J R Goulder
P2860
P304
P356
10.1084/JEM.20072457
P407
P577
2008-04-21T00:00:00Z