Optimization of binding electrostatics: charge complementarity in the barnase-barstar protein complex.
about
Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 proteaseCrystal structural analysis of protein-protein interactions drastically destabilized by a single mutationFactors influencing the energetics of electron and proton transfers in proteins. What can be learned from calculations.Analysis of fast boundary-integral approximations for modeling electrostatic contributions of molecular bindingProteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand bindingApplication of new multi-resolution methods for the comparison of biomolecular electrostatic properties in the absence of global structural similarityPrediction of protein-protein interaction sites using electrostatic desolvation profiles.Electrostatic contributions to T4 lysozyme stability: solvent-exposed charges versus semi-buried salt bridges.Differences in electrostatic properties at antibody-antigen binding sites: implications for specificity and cross-reactivity.Profiling charge complementarity and selectivity for binding at the protein surface.Comparison of calculation and experiment implicates significant electrostatic contributions to the binding stability of barnase and barstarA numerically stable restrained electrostatic potential charge fitting method.The effect of macromolecular crowding on the electrostatic component of barnase-barstar binding: a computational, implicit solvent-based study.Robust protein protein interactions in crowded cellular environments.Biophysical limits of protein-ligand binding.Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.Accurate solution of multi-region continuum biomolecule electrostatic problems using the linearized Poisson-Boltzmann equation with curved boundary elements.A "Reverse-Schur" Approach to Optimization With Linear PDE Constraints: Application to Biomolecule Analysis and DesignCharge Optimization Theory for Induced-Fit Ligands.Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems.Computational methods for biomolecular electrostatics.Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptorsExploring the origins of binding specificity through the computational redesign of calmodulin.Efficient determination of protein-protein standard binding free energies from first principles.Kinetic and affinity predictions of a protein-protein interaction using multivariate experimental design.Optimization of electrostatic interactions in protein-protein complexes.The efficiency of different salts to screen charge interactions in proteins: a Hofmeister effect?How optimal are the binding energetics of barnase and barstar?Quantum mechanical calculation of electric fields and vibrational Stark shifts at active site of human aldose reductase.The role of charged surface residues in the binding ability of small hubs in protein-protein interaction networksDynamics of Hydration Water Plays a Key Role in Determining the Binding Thermodynamics of Protein Complexes.Electrostatic properties of protein-protein complexes.On the electrostatic component of protein-protein binding free energy.Action-at-a-distance interactions enhance protein binding affinity.Context-dependent mutations predominate in an engineered high-affinity single chain antibody fragment.Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity.Identification of a functional site on the type I TGF-beta receptor by mutational analysis of its ectodomain.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.Evaluation of electrostatic interactions.Improved flexible refinement of protein docking in CAPRI rounds 22-27.
P2860
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P2860
Optimization of binding electrostatics: charge complementarity in the barnase-barstar protein complex.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Optimization of binding electr ...... rnase-barstar protein complex.
@ast
Optimization of binding electr ...... rnase-barstar protein complex.
@en
type
label
Optimization of binding electr ...... rnase-barstar protein complex.
@ast
Optimization of binding electr ...... rnase-barstar protein complex.
@en
prefLabel
Optimization of binding electr ...... rnase-barstar protein complex.
@ast
Optimization of binding electr ...... rnase-barstar protein complex.
@en
P2860
P356
P1433
P1476
Optimization of binding electr ...... arnase-barstar protein complex
@en
P2093
P2860
P304
P356
10.1110/PS.40001
P50
P577
2001-02-01T00:00:00Z