Innovative lead discovery strategies for tropical diseases.
about
A "reverse pharmacology" approach for developing an anti-malarial phytomedicine.Identification of attractive drug targets in neglected-disease pathogens using an in silico approachDrug target prediction and prioritization: using orthology to predict essentiality in parasite genomesNew approaches to filling the gap in tuberculosis drug discoveryGenomic-scale prioritization of drug targets: the TDR Targets databaseIdentification of oxadiazoles as new drug leads for the control of schistosomiasisKinases as druggable targets in trypanosomatid protozoan parasitesDrug repurposing and human parasitic protozoan diseasesTrypanocidal activity of marine natural productsCaspase dependent programmed cell death in developing embryos: a potential target for therapeutic intervention against pathogenic nematodesDrug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screeningEfficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein FarnesyltransferaseInhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction IntermediateTrypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen HitOptimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate SynthetaseDihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein CrystallographyStructural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoniTraditional medicines as a mechanism for driving research innovation in AfricaAntileishmanial high-throughput drug screening reveals drug candidates with new scaffoldsMefloquine--an aminoalcohol with promising antischistosomal properties in miceAssay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoniA kernel for open source drug discovery in tropical diseasesDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisAdvancing drug innovation for neglected diseases-criteria for lead progressionA novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motilityThe susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposingInnovative partnerships for drug discovery against neglected diseasesIntegrated dataset of screening hits against multiple neglected disease pathogensA screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hitCombined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivoDiverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanismIn vitro susceptibilities of wild and drug resistant leishmania donovani amastigote stages to andrographolide nanoparticle: role of vitamin E derivative TPGS for nanoparticle efficacyMemantine, an antagonist of the NMDA glutamate receptor, affects cell proliferation, differentiation and the intracellular cycle and induces apoptosis in Trypanosoma cruziDevelopment and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoniIdentification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaignActivity Profile of an FDA-Approved Compound Library against Schistosoma mansoniThe Validation of Nematode-Specific Acetylcholine-Gated Chloride Channels as Potential Anthelmintic Drug TargetsDiscovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis
P2860
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P2860
Innovative lead discovery strategies for tropical diseases.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Innovative lead discovery strategies for tropical diseases.
@ast
Innovative lead discovery strategies for tropical diseases.
@en
type
label
Innovative lead discovery strategies for tropical diseases.
@ast
Innovative lead discovery strategies for tropical diseases.
@en
prefLabel
Innovative lead discovery strategies for tropical diseases.
@ast
Innovative lead discovery strategies for tropical diseases.
@en
P2860
P356
P1476
Innovative lead discovery strategies for tropical diseases.
@en
P2093
Alan Hudson
Solomon Nwaka
P2860
P2888
P304
P356
10.1038/NRD2144
P577
2006-11-01T00:00:00Z