Possible mechanism of miltefosine-mediated death of Leishmania donovani.
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Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasisIn-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleriNelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotesIn vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasitesImipramine is an orally active drug against both antimony sensitive and resistant Leishmania donovani clinical isolates in experimental infectionReactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveformGlyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxificationPhospholipid and sphingolipid metabolism in Leishmania.Immunotherapy and Immunochemotherapy in Visceral Leishmaniasis: Promising Treatments for this Neglected Disease.Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stressA Computational Methodology to Overcome the Challenges Associated With the Search for Specific Enzyme Targets to Develop Drugs Against Leishmania major.Synthetic neoglycoconjugates of cell-surface phosphoglycans of Leishmania as potential anti-parasite carbohydrate vaccinesMonitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP.Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.Gallic and ellagic acids: two natural immunomodulator compounds solve infection of macrophages by Leishmania major.Mechanisms of action of lysophospholipid analogues against trypanosomatid parasites.Miltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management.In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.Treatment of leishmaniasis with miltefosine: 2008 status.Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis.In-vitro Evaluation of Antileishmanial Activity and Toxicity of Artemether with Focus on its Apoptotic Effect.Metacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensisTargeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death.Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania.Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis.VOSalophen: a vanadium complex with a stilbene derivative-induction of apoptosis, autophagy, and efficiency in experimental cutaneous leishmaniasis.Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani.Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.Perifosine Mechanisms of Action in Leishmania Species.Miltefosine-induced apoptotic cell death on Leishmania major and L. tropica strains.Flow cytometric screening for anti-leishmanials in a human macrophage cell line.Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes.Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis.Efficacy of tamoxifen and miltefosine combined therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis.MAPK1 of Leishmania donovani modulates antimony susceptibility by downregulating P-glycoprotein efflux pumps.Drug resistance in leishmaniasis.An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1.Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.
P2860
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P2860
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@ast
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@en
type
label
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@ast
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@en
prefLabel
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@ast
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@en
P2860
P1476
Possible mechanism of miltefosine-mediated death of Leishmania donovani.
@en
P2093
Chinmoy S Dey
Navin K Verma
P2860
P304
P356
10.1128/AAC.48.8.3010-3015.2004
P407
P577
2004-08-01T00:00:00Z