Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice. - Wikidata - awgldk - TriplyDB

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.

http://www.wikidata.org/entity/Q36670692

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Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration Plant cell nucleolus as a hot spot for iron Neuroferritinopathy: From ferritin structure modification to pathogenetic mechanism Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration.The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Late-onset neurodegeneration with brain iron accumulation with diffusion tensor magnetic resonance imaging The role of iron in brain ageing and neurodegenerative disorders.Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy.Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.Ferritin enhances SPIO tracking of C6 rat glioma cells by MRI.Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy.Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration.Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.Systemic and cerebral iron homeostasis in ferritin knock-out mice.Behavioral characterization of mouse models of neuroferritinopathy.Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage.Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits.Mammalian iron metabolism and its control by iron regulatory proteins Abnormal iron homeostasis and neurodegeneration.Iron loaded ferritin secretion and inhibition by CI-976 in Aedes aegypti larval cells Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice.Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration.Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration.MRI findings in neuroferritinopathy.Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro.Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.Magnetic resonance imaging of cells in experimental disease models.Nurr1 and PPARγ protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment.Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment.Assessment of MR-based R2* and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T.Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress A Selection of Important Genes and Their Correlated Behavior in Alzheimer's Disease

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P2860

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.

http://www.wikidata.org/entity/Q36670692

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Expression of a mutant form of ...... n overload in transgenic mice.

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Expression of a mutant form of ...... n overload in transgenic mice.

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JNEUROSCI.3962-07.2008

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Journal of Neuroscience

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Expression of a mutant form of ...... n overload in transgenic mice.

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Ana G Barbeito

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Bernardino Ghetti

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Leticia Miravalle

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Mario Widel

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Martin A Baraibar

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Navin Bansal

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Ruben Vidal

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Shahryar K Hekmatyar

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Xiaoying Gao

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P2860

A stop-codon mutation in the BRI gene associated with familial British dementia

The ferritins: molecular properties, iron storage function and cellular regulation

Role of iron in neurodegenerative disorders.

Specific repression of beta-globin promoter activity by nuclear ferritin

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease.

Chaperoning brain degeneration.

The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications.

Neurodegeneration: what is it and where are we?

Hereditary ferritinopathy.

Iron status and neural functioning.

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60-67

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10.1523/JNEUROSCI.3962-07.2008

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1

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Marie Bernadette Delisle

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2008-01-01T00:00:00Z

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5677730

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2394191

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