Aminopeptidase A inhibitors as potential central antihypertensive agents
about
Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidasesInsights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl AminopeptidaseStructural Insights into Central Hypertension Regulation by Human Aminopeptidase AEnzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IVApelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin releaseInvolvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cellsThe impact of ANG II and IV on INS-1 cells and on blood glucose and plasma insulin.Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidaseBrain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertensionNew drug therapies interfering with the renin-angiotensin-aldosterone system for resistant hypertension.Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.Bioactive angiotensin peptides: focus on angiotensin IV.Proteolytic processing of angiotensin-I in human blood plasma.Cellular targets for angiotensin II fragments: pharmacological and molecular evidence.Angiotensin II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell lineTuned by metals: the TET peptidase activity is controlled by 3 metal binding sites.Brain aminopeptidases and hypertension.Association study: the aminopeptidase a gene and essential hypertensionMechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control.Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction.Advances in understanding the renin-angiotensin-aldosterone system (RAAS) in blood pressure control and recent pivotal trials of RAAS blockade in heart failure and diabetic nephropathy.Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect.Blood pressure and renal hemodynamic effects of angiotensin fragments.High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism.Neuroendocrine Regulation of Hydromineral Homeostasis.Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension.Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid.Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residuesDistinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes.Collagen production in cardiac fibroblasts during inhibition of aminopeptidase B.The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A.Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity.Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons.Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats.Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction.Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei.Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems.
P2860
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P2860
Aminopeptidase A inhibitors as potential central antihypertensive agents
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Aminopeptidase A inhibitors as potential central antihypertensive agents
@ast
Aminopeptidase A inhibitors as potential central antihypertensive agents
@en
type
label
Aminopeptidase A inhibitors as potential central antihypertensive agents
@ast
Aminopeptidase A inhibitors as potential central antihypertensive agents
@en
prefLabel
Aminopeptidase A inhibitors as potential central antihypertensive agents
@ast
Aminopeptidase A inhibitors as potential central antihypertensive agents
@en
P2093
P2860
P356
P1476
Aminopeptidase A inhibitors as potential central antihypertensive agents
@en
P2093
B P Roques
C Llorens-Cortes
M C Fournie-Zaluski
P2860
P304
13415-13420
P356
10.1073/PNAS.96.23.13415
P407
P577
1999-11-01T00:00:00Z