Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.
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CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulationT helper cell activation and human retroviral pathogenesisThe role of B7 costimulation in T-cell immunity.The in vivo mechanism of action of CTLA4IgFollicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.Down-regulation of Th2 responses by Brucella abortus, a strong Th1 stimulus, correlates with alterations in the B7.2-CD28 pathwayBone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytesCTLA4 mediates antigen-specific apoptosis of human T cells.Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipientsSpecific T-cell tolerance may be preceded by a primary response.Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells.Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2.Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28, and their mRNA in inflammatory myopathies.Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergyB70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaBMajor histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cellsB7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics.Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.Role of B cells in antigen presentation of the hepatitis B core.Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection.Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells.Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice.Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells.B7 costimulation plays an important role in protection from herpes simplex virus type 2-mediated pathology.CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs.Exaggerated and persistent cutaneous delayed-type hypersensitivity in transgenic mice whose epidermal keratinocytes constitutively express B7-1 antigen.Effect of crossmatching on outcome in organ transplantation.Differential downstream effects of CD40 ligation mediated by membrane or soluble CD40L and agonistic Ab: a study on purified human B cells.The antigen-presenting cell function of Reed-Sternberg cells.CD28: a signalling perspective.Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells. Convergence of costimulatory signals and differences from transformed T cells.The western-type diet induces anti-HMGB1 autoimmunity in Apoe(-/-) mice.
P2860
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P2860
Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Activated human B lymphocytes ...... costimulate T-cell activation.
@ast
Activated human B lymphocytes ...... costimulate T-cell activation.
@en
type
label
Activated human B lymphocytes ...... costimulate T-cell activation.
@ast
Activated human B lymphocytes ...... costimulate T-cell activation.
@en
prefLabel
Activated human B lymphocytes ...... costimulate T-cell activation.
@ast
Activated human B lymphocytes ...... costimulate T-cell activation.
@en
P2093
P2860
P356
P1476
Activated human B lymphocytes ...... costimulate T-cell activation.
@en
P2093
G J Freeman
J G Gribben
L M Nadler
V A Boussiotis
P2860
P304
11059-11063
P356
10.1073/PNAS.90.23.11059
P407
P577
1993-12-01T00:00:00Z