p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation
about
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 productionGrowth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signalingFYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsMultiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesSignaling in Effector Lymphocytes: Insights toward Safer ImmunotherapyCell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionThe Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer CellsThe Molecular Interaction of CAR and JAML Recruits the Central Cell Signal Transducer PI3KUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingThe anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cellsCD28 and CTLA-4 coreceptor expression and signal transductionLck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activityTwo distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase associationGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionThe role of Tec protein-tyrosine kinase in T cell signalingFyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cellsQuantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.An enigmatic tail of CD28 signaling.Mechanisms of interleukin-10-mediated immune suppression.Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling.T-cell regulation by CD28 and CTLA-4.The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.Itk: the rheostat of the T cell response.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase.Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras.Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinaseTargeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationRegulation of T-cell responses by PTENT cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodesCytoskeleton-membrane interactions in membrane raft structure.Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobilitySpatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells.Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters.CD28 co-signaling in the adaptive immune response.
P2860
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P2860
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@ast
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en-gb
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@nl
type
label
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@ast
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en-gb
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@nl
prefLabel
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@ast
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en-gb
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@nl
P2093
P2860
P3181
P356
P1476
p56Lck and p59Fyn regulate CD2 ...... tions for T-cell costimulation
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.92.19.8891
P407
P577
1995-09-01T00:00:00Z