Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons - Wikidata - awgldk - TriplyDB

Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons

Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons

http://www.wikidata.org/entity/Q36691036

about

Genetic manipulation in pigs Immune modulation in xenotransplantation Cardiac xenotransplantation: progress and challenges Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs Coagulation dysregulation as a barrier to xenotransplantation in the primate Controlling coagulation dysregulation in xenotransplantation.Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation.Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons Immunobiology of liver xenotransplantation.Increased transfusion-free survival following auxiliary pig liver xenotransplantation.Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens.Further evidence for sustained systemic inflammation in xenograft recipients (SIXR).The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation Cytokine profiles in Tibetan macaques following α-1,3-galactosyltransferase-knockout pig liver xenotransplantation.Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons.Overcoming the barriers to xenotransplantation: prospects for the future Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs.The role of genetically engineered pigs in xenotransplantation research.Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen.Effect of hyperkalemia and hemolysis caused by hyperacute rejection on cardiac function in pig to human ex vivo xenogeneic cardiac perfusion model.Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs Alpha 1,3-galactosyltransferase deficiency in pigs increases sialyltransferase activities that potentially raise non-gal xenoantigenicity.Protection of porcine endothelial cells against apoptosis with interleukin-4.Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts.Recent investigations into pig antigen and anti-pig antibody expression Current status of pig heart xenotransplantation.Which anti-platelet therapies might be beneficial in xenotransplantation?Xenotransplantation as a model of integrated, multidisciplinary research Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: a pilot study.Complement activation and coagulation in xenotransplantation.Rat-to-Chinese tree shrew heart transplantation is a novel small animal model to study non-Gal-mediated discordant xenograft humoral rejection.Immunological challenges and therapies in xenotransplantation.The anti-nonGal xenoantibody response to alpha1,3-galactosyltransferase gene knockout pig xenografts.Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era.

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P2860

Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons

http://www.wikidata.org/entity/Q36691036

description

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Thrombotic microangiopathy ass ...... gene-knockout pigs in baboons

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The American Journal of Pathology

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Thrombotic microangiopathy ass ...... gene-knockout pigs in baboons

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Akira Shimizu

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David H Sachs

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David K C Cooper

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Frank J M F Dor

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Henk-Jan Schuurman

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Kazuhiko Yamada

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Kenji Kuwaki

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Robert B Colvin

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Simon C Robson

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Stuart L Houser

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P2860

Loss of ATP diphosphohydrolase activity with endothelial cell activation

alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months

Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity.

Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption.

Factors in xenograft rejection.

The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies.

Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.

Production of alpha 1,3-galactosyltransferase-deficient pigs.

Physiologic and immunologic hurdles to xenotransplantation.

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.

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1471-1481

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18467706

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