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The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresomep62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnoverFormin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenanceEssential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosisUbiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradationTitin, a Central Mediator for Hypertrophic Signaling, Exercise-Induced Mechanosignaling and Skeletal Muscle RemodelingRole of p62/SQSTM1 in liver physiology and pathogenesisStructural basis for sorting mechanism of p62 in selective autophagyp62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 bindingIndividual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.Transcriptomic changes arising during light-induced sporulation in Physarum polycephalumFunctional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.Autophagy in unicellular eukaryotesActivation of JNK and IRE1 is critically involved in tanshinone I-induced p62 dependent autophagy in malignant pleural mesothelioma cells: implication of p62 UBA domain.Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors.Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsThe sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection.Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of boneRegulation of autophagy by neuropathological protein TDP-43.Disruption of protein quality control in Parkinson's disease.Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells.Keap1 degradation by autophagy for the maintenance of redox homeostasisOxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).Autophagy in toxicology: self-consumption in times of stress and plenty.Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stressUbiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease.Molecular pathology of myofibrillar myopathies.Proteomic investigation of the time course responses of RAW 264.7 macrophages to infection with Salmonella entericaSize, organization, and dynamics of soluble SQSTM1 and LC3-SQSTM1 complexes in living cellsSequestosome-1/p62 is the key intracellular target of innate defense regulator peptide.Screening of differentially expressed genes associated with non-union skeletal fractures and analysis with a DNA microarray.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Sequestosome 1/p62--more than just a scaffold.
@ast
Sequestosome 1/p62--more than just a scaffold.
@en
type
label
Sequestosome 1/p62--more than just a scaffold.
@ast
Sequestosome 1/p62--more than just a scaffold.
@en
prefLabel
Sequestosome 1/p62--more than just a scaffold.
@ast
Sequestosome 1/p62--more than just a scaffold.
@en
P2093
P2860
P1433
P1476
Sequestosome 1/p62--more than just a scaffold.
@en
P2093
M Lamar Seibenhener
Marie W Wooten
Thangiah Geetha
P2860
P304
P356
10.1016/J.FEBSLET.2006.12.027
P407
P577
2006-12-19T00:00:00Z