Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen.
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Association of insulin receptor substrate 1 with simian virus 40 large T antigenStructural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigenTransactivation of a ribosomal gene by simian virus 40 large-T antigen requires at least three activities of the protein.The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.Activation of RNA polymerase III transcription in cells transformed by simian virus 40Enumeration of the simian virus 40 early region elements necessary for human cell transformationRegions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts.T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisSmall tumor antigen of polyomaviruses: role in viral life cycle and cell transformationAbolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts.The carboxy terminus of simian virus 40 large T antigen is required to disrupt the yeast cell cycleCharacterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donorsSimian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107.A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.Differential interaction of temperature-sensitive simian virus 40 T antigens with tumor suppressors pRb and p53Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53Immortalized functional endothelial progenitor cell lines from umbilical cord blood for vascular tissue engineering.Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen.Association of p300 and CBP with simian virus 40 large T antigenThe amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigenEfficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigenUse of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant.Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutationsMechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.Overproduction of Rb protein after the G1/S boundary causes G2 arrest.High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism.Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation.The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts.Polyomavirus T antigens: molecular chaperones for multiprotein complexes.LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene.Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.The inhibition of cultured myoblast differentiation by the simian virus 40 large T antigen occurs after myogenin expression and Rb up-regulation and is not exerted by transformation-competent cytoplasmic mutants.Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.Gas1-induced growth suppression requires a transactivation-independent p53 function.Simian virus 40 large T antigen host range domain functions in virion assembly.
P2860
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P2860
Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Transformation of a continuous ...... mian virus 40 large T antigen.
@ast
Transformation of a continuous ...... mian virus 40 large T antigen.
@en
type
label
Transformation of a continuous ...... mian virus 40 large T antigen.
@ast
Transformation of a continuous ...... mian virus 40 large T antigen.
@en
prefLabel
Transformation of a continuous ...... mian virus 40 large T antigen.
@ast
Transformation of a continuous ...... mian virus 40 large T antigen.
@en
P2093
P2860
P1433
P1476
Transformation of a continuous ...... imian virus 40 large T antigen
@en
P2093
P2860
P304
P407
P577
1992-05-01T00:00:00Z